1. [Consciousness disorders and severe haemolytic anaemia in a patient coming from overseas].
- Author
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Garcia-Hejl C, Thefenne-Astier H, Navarrot JC, Batjom E, Nicand E, Ricordel Y, Ramirez JM, and Brinquin L
- Subjects
- Diagnosis, Differential, Diarrhea etiology, Fatal Outcome, Glucosephosphate Dehydrogenase Deficiency complications, Guinea ethnology, Headache etiology, Humans, Lymphohistiocytosis, Hemophagocytic etiology, Malaria, Falciparum diagnosis, Male, Methemoglobinemia etiology, Middle Aged, Multiple Organ Failure etiology, Paris, Seizures etiology, Vomiting etiology, Anemia, Hemolytic etiology, Antithyroid Agents adverse effects, Glucosephosphate Dehydrogenase Deficiency diagnosis, Methemoglobinemia chemically induced, Methimazole adverse effects, Psychomotor Agitation etiology
- Abstract
A 54-years-old patient coming from Guinea, who presented fever, diarrhoea, consciousness disorders and severe haemolytic anaemia, was admitted to resuscitation unit in France. Despite many explorations carried out (evaluation of traumatic causes, infection, neoplasia, vascular, toxic causes, vitamin deficiency), it was not possible to explain neurological symptomatology. Besides, haemolytic anaemia was due to the ingestion of metamizole in a context of glucose-6-phosphate dehydrogenase deficit. This drug's marketing has been suspended in France since 2006. Despite appropriate treatment, after seven days of hospitalization, the patient died of multi-organ failure and hemophagocytic syndrome. This clinical case illustrates the difficulties encountered to set a diagnosis and manage patients coming from overseas. Uncommon aetiologies for French healthcare professionals should be evoked in the absence of comprehensive clinical information.
- Published
- 2008
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