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This paper contributes to the discussion on climate change impacts, livelihood diversification, and deagrarianization in arid and semi-arid regions. Using the semi-arid region of Guinea as a case study, this paper is the first to discuss the primary factors driving smallholder farmers into artisanal and small-scale mining (ASM) in arid and semi-arid regions. Drawing on in-depth interviews and root-cause analysis, we find that increasing climate change impacts 'force' smallholder farmers to switch into artisanal gold mining. Smallholder farming in semi-arid Guinea is largely rainfed and erratic rainfall and increasing temperatures have affected crop production and farmers' income, driving many smallholder farmers into artisanal gold mining to have a more sustainable income. While artisanal gold mining has improved smallholder farmers' socioeconomic conditions, the agriculture exodus has significantly affected crop production, food prices, and rural agriculture labor dynamics. Agroecological, financial, and technical support could improve the adaptive capacity of climate impacted smallholder farmers in arid and semi-arid regions. • Agrarian communities are now transforming into artisanal mining communities due primarily to climate change. • Dry farmlands, low farm productivity, and low farm income are secondary factors that drive farmers into the ASM economy. • Farmers converted to miners to cope with climate change impacts and not necessarily to 'get rich quick'. • Smallholder farmers in semi-arid Guinea lack access to climate adaptive strategies. • Livelihood diversification from farming to ASM affects rural socioeconomics and threatens food security. [ABSTRACT FROM AUTHOR]