Search

The Ebola virus disease epidemic that threatened West Africa between 2013 and 2016 was of unprecedented health magnitude. After this health crisis, studies highlighted the need to introduce community-based surveillance systems and to adopt a One Health approach. This study aimed to provide preparatory insights for the definition of a community-based surveillance system for emerging zoonoses such as viral hemorrhagic fevers in Guinea. The objective was to explore the disease detection capacity and the surveillance network opportunities at the community level in two pilot areas in the forest region of Guinea, where the epidemic emerged. Based on a participatory epidemiological and One Health approach, we conducted Focus Group Discussions with human, animal and ecosystem health actors. We used a range of participatory tools, included semi-structured interviews, ranking, scoring and flow diagram, to estimate the local knowledge and perception of diseases and clinical signs and to investigate the existing health information exchange network and its related strengths and weaknesses. The results showed that there is heterogeneity in knowledge of diseases and perception of the clinical signs among actors and that there are preferred and more effective health communication channels opportunities. This preparatory study suggests that it is necessary to adapt the case definitions and the health communication channels to the different actors who can play a role in a future community-based surveillance system and provides recommendations for future surveillance activities to be carried out in West Africa. Author summary: Viral hemorrhagic diseases have a high risk of emergence in tropical regions. The consequences on public health are often disastrous in the low- and middle-income countries that face difficulties to control epidemics. This scenario has unfortunately occurred in West Africa between 2013 and 2016 with the Ebola virus disease epidemic. There is an urgent need to increase the capacity for rapid detection of the emergence of such diseases and adopting a One Health approach since most of them are zoonotic. Community-based surveillance seems appropriate to address this issue in the context of these countries. We collected preparatory data through semi-structured interviews of community actors in human health, animal health and ecosystem health in Guinea. We used participatory epidemiology that appears to be a consistent method to assess local knowledge and perceptions of diseases and clinical signs and to identify health information exchange network opportunities. We aimed to provide relevant recommendations for the design of adapted case definitions and surveillance network in the prospect of implementing a community-based surveillance system of viral hemorrhagic fevers in Guinea and future surveillance activities to be carried out in West Africa. [ABSTRACT FROM AUTHOR]

The development of sorghum [Sorghum bicolor (L.) Moench] hybrids with Guinea‐race parents is a promising approach to increase yields in West Africa (WA). There is heretofore no quantitative genetic information about the genetic value of new hybrids and their parents, or about the efficiency of alternative selection methods for targeting yield performance under the predominantly low‐input, P‐deficient production conditions. This study aims to estimate the heterosis levels attainable by new Guinea‐race hybrids and the combining abilities of the current suite of parents with partial‐ to full‐Guinea‐race backgrounds of contrasting geographic origins, and to determine the effectiveness of direct selection under low‐P (LP) relative to indirect selection under high‐P (HP) conditions. Single‐cross hybrids were evaluated in 2015 and 2016 for yield under both LP and HP conditions at two locations in Mali. The hybrid yields were substantially superior to farmers' local Guinea‐race varieties, with 20 to 80% higher means in both LP and HP environments. Average midparent and better‐parent heterosis estimates were, respectively, 78 and 48% under HP, and 75 and 42% under LP. Direct selection for yield under LP was predicted to be 20 to 60% more effective than indirect selection under HP conditions. The combining ability estimates provided initial insights into the potential benefit of germplasm from more eastern and humid regions of WA for developing a restorer pool distinct and complementary to the female pool from Mali and surrounding countries. Substantial yield superiorities of hybrids over local varieties suggested that a hybrid breeding strategy based on Guinea germplasm could help improve WA smallholder farmers' livelihood. [ABSTRACT FROM AUTHOR]

Abstract: Ethnopharmacological relevance: This survey was carried out in the coastal lowlands of Guinea–Conakry in order to make an inventory of plants used by traditional healers, herbalists and diabetic patients for the management of diabetes mellitus. Materials and methods: Frequent ethnomedical and ethnobotanical investigations were conducted from June 2008 to December 2009 in Conakry, Kindia, Forécariah, Dubréka, Boke, Fria and Boffa. It is a cross-sectional survey and data collection is based on the interactive method. During this period a total of 112 people aged from 39 to 76 years old were interviewed. Results: During this investigation 146 plant species belonging to 55 families were collected. The most cited plants were Anacardium occidentale L. and Ficus spp., while the Fabaceae family was the most represented, followed by the Euphorbiaceae and Rubiaceae. The most frequently plant parts used by the traditional healers and the herbalists were the stem-bark and decoctions the most common preparation mode. Conclusions: It is clear that a variety of plants is used in the management and treatment of diabetes. Due to the increasing prevalence of type 2 diabetes, there is an urgent need for scientific investigations to rationalise the use of these traditional remedies, which could represent accessible alternative medicines for the Guinean populations. [Copyright &y& Elsevier]

Based on an ethnobotanical survey, 41 Guinean plant species widely used in the traditional treatment of fever and/or malaria were collected. From these, 74 polar and apolar extracts were prepared and tested for their in vitro antiprotozoal activity along with their cytotoxicity on MRC-5 cells. A potent activity (IC50 < 5 µg/mL) was observed for Terminalia albida, Vismia guineensis, Spondias mombin, and Pavetta crassipes against Plasmodium falciparum; for Pavetta crassipes, Vismia guineensis, Guiera senegalensis, Spondias mombin, Terminalia macroptera, and Combretum glutinosum against Trypanosoma brucei brucei; for Bridelia ferruginea, G. senegalensis, V. guineensis, P. crassipes, and C. glutinosum against Trypanosoma cruzi. Only the extract of Tetracera alnifolia showed a good activity (IC50 8.1 µg/mL) against Leishmania infantum. The selectivity index of the active samples varied from 0.08 to > 100. These results may validate at least in part the traditional use of some of the plant species., (Georg Thieme Verlag KG Stuttgart · New York.)