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Human exposure to bisphenol A (BPA) and bisphenol S (BPS) has garnered considerable global health concerns. In this paper, the daily intake (DI) of BPA and BPS in the general population of Guangzhou, China, were back-calculated using the biomarkers BPA glucuronides (BPA-G) and BPS glucuronides (BPS-G), respectively. The biomarkers are preferable to total BPA and BPS measurements because they are not susceptible to external contamination. A total of 1440 urine samples were gathered from the general population in Guangzhou, China, which were classified by age and sex into 36 pooled urine samples. 100% and 98% of pooled urine samples contained BPA-G and BPS-G at median values of 1.57 and 0.38 ng/mL, respectively. Based on urinary BPA-G and BPS-G concentrations, we determined the median DI of BPA and BPS to be 31.07 and 7.37 ng/(kg bw*d), respectively, and the highest values to be 106.77 ng/(kg bw*d) and 18.19 ng/(kg bw*d), respectively. Furthermore, our results showed that for the entire dataset, the DI of BPA and BPS were considerably greater in males than in females (p < 0.01)and declined significantly with age (p < 0.05). For risk assessment, the estimated DIs of BPA and BPS were much lower than the European Food Safety Authority' s (EFSA) the temporary acceptable reference dose of 4 μg/(kg bw*d) advised for BPA, suggesting that the exposure risk of BPA and BPS for Guangzhou population is within a controllable safety range. This is the first study to investigate BPA and BPS exposure in the general population of Guangzhou, China, on the basis of urinary metabolites. [Display omitted] • Urinary concentration profiles of the glucuronide conjugates of BPA and BPS were provided. • Human exposure to BPA and BPS was assessed via urinary metabolites. • The relationship between BPA and BPS exposure and gender and age was determined. [ABSTRACT FROM AUTHOR]

Phthalate esters (PAEs) were examined in indoor and outdoor dust samples from the subtropical city of Guangzhou, China. The ∑PAEs concentrations ranged from 121 to 3,223 μg g dust, with the median concentration of 840 μg g dust. Significantly higher concentrations of PAEs in dust samples were found in offices where electrical and electronic devices, carpet pads, and office furniture were widely used. Of the 16 PAEs, diisobutyl phthalate (D iBP), di- n-butyl phthalate (D nBP), and di(2-ethylhexyl) phthalate (DEHP) dominated the PAEs in indoor and outdoor dust samples, and accounted for >96.8% and >93.1% of the ∑PAEs concentrations, respectively. The median daily inhalation exposure of ∑PAEs were 3.53 and 0.247 μg kg body weight day, and at the 95 percentile were 7.62 and 0.530 μg kg body weight day, up on the measured concentrations and estimated dust ingestion rates, respectively, for toddles and adults. The ubiquitous distribution of PAEs as noted in this study suggests the need for detailed assessment of PAEs concentrations using more sites and to further investigate the factors influencing PAEs exposure in China. [ABSTRACT FROM AUTHOR]

Abstract: Urban lakes are vulnerable to the accumulation of toxic and/or potentially toxic contaminants, such as phthalate esters (PAEs) from urban stormwater runoff, atmospheric deposition, as well as untreated discharge of industrial wastewater and municipal sewage. The concentrations of 16 PAEs in surface water from 15 urban lakes in the subtropical city, Guangzhou, were measured, respectively in spring, summer and winter 2006, to elucidate the effect of the seasonal variation in climate conditions on the distribution of PAEs. Seasonal variations of the Σ16PAEs concentrations, ranging, respectively from 0.47 to 6.19μgL−1 and from 24.9 to 221μgg−1, were measured in the dissolved and suspended particulate matter (SPM) phases. The highest concentrations of PAEs were present in summer. The spatial distribution of PAEs was site-specific. Of the 16 PAEs, dimethyl phthalate (DMP), diethyl phthalate (DEP), diisobutyl phthalate (DiBP), di-n-butyl phthalate (DnBP), di(4-methyl-2-pentyl) phthalate (DMPP), di(2-ethylhexyl) phthalate (DEHP) were present in all the samples analyzed, and dominated by DnBP, DiBP and DEHP. Composition profile of PAEs indicated that the application of DnBP/DiBP is relatively high in the Pearl River Delta (PRD). Longer/branching alkyl PAEs likely adsorb to SPM in aquatic environments. Normalized partition coefficient (K OC) between the dissolved water and SPM was correlated with n-octanol/water partition coefficient (K OW) to understand the environmental behavior of PAEs. [Copyright &y& Elsevier]

Abstract: Surface soils from 37 sampling sites including roadsides (RS), parks (PA) and residential areas (RE) of the Subtropical City, Guangzhou, were collected in December of 2005 and analyzed for 16 phthalate esters (PAEs). PAEs were detected in all surface soils analyzed, which indicate that PAEs are ubiquitous environmental contaminants. The concentrations ranged from 1.67 to 322μgg−1-dry weight (dw), with the median concentration of 17.7μgg−1-dw, mainly originating from municipal solid waste leachate, discarded plastic effusion, municipal sewage and atmospheric depositions. Concentrations of PAEs were poorly correlated with soil organic carbon content, suggesting mixing process between local and on-going sources. Of the 16 PAEs, diisobutyl phthalate (DiBP), di-n-butyl phthalate (DnBP) and di(2-ethylhexyl) phthalate (DEHP) dominated the PAEs, with the median concentrations of 1.63μgg−1-dw, 1.80μgg−1-dw and 14.8μgg−1-dw, respectively, and accounted for 74.2–99.8% of the concentrations. Principal Component Analysis (PCA) was applied to the distribution patterns of PAEs in the urban soils. Significant correlations existed among DiBP, DnBP, and DEHP, and between dimethyl phthalate (DMP) and diethyl phthalate (DEP). No significant differences of PAE congeneric profiles were observed between this and studies conducted elsewhere, which is consistent with the application of similar commercial PAEs around the world. As compared to the results from other studies, the urban soils of Guangzhou city were severely contaminated with PAEs. The environmental and human health risks posed by PAEs in the urban soils of Guangzhou city may deserve further attention. [Copyright &y& Elsevier]

67 soil samples from the road greenbelts, the paddy/vegetable fields, the parks, the commercial and residential areas in the subtropical city, Guangzhou, China, were collected and analyzed for 11 organophosphate esters (OPEs) and triphenylphosphine oxide (TPPO). OPEs were detected in all soil samples analyzed, which indicate that OPEs are ubiquitous environmental contaminants. The ∑ 11 OPEs concentrations ranged from 0.041 mg kg −1 -dry weight (dw) to 1.37 mg kg −1 -dw, with the mean and median concentrations of 0.25 mg kg −1 -dw and 0.24 mg kg −1 -dw, respectively. High concentrations of OPEs were observed in the roadside soils collected from the commercial areas with heavy traffic and extensive anthropogenic activities. Of 11 OPEs, tris(2-butoxyethyl) phosphate (TBOEP), tri-cresyl-phosphate (TMPP), tributyl phosphate (TNBP) and tris(2-chloroethyl) phosphate (TCEP) were the most abundant OPEs, contributing 42.8 ± 15.4%, 17.2 ± 11.9%, 10.9 ± 6.85% and 9.70 ± 9.56% of ∑ 11 OPEs, respectively. Principal component analysis (PCA) suggested that OPEs accumulation in the urban soils derived from different sources. As compared to the results for other studies, the urban soils of Guangzhou were moderately polluted by OPEs. [ABSTRACT FROM AUTHOR]

Bisphenol analogues (BPs) are ubiquitous in the environment and have gained significant attention regarding their associated health risks. However, there is a lack of comprehensive biomonitoring data on BPs and their metabolites in human urine. To address this, we conducted a study evaluate the exposure to BPs in the general population of Guangzhou, China. A total of 1440 urine samples were collected from volunteers and analyzed for the presence of BPs and their metabolites after being pooled into 36 groups based on age and gender. The findings revealed the common detection of ten free-form BPs, as well as the urinary metabolites of BPA and BPS, in the pooled urine samples. BPA was the predominant free-form compound, constituting 50% of the total BPs. The primary urinary metabolites of BPA and BPS are BPA-G and BPS-G, respectively, indicating glucuronidation as their primary metabolic pathway. The composition of urinary metabolites of BPA and BPS varied by age and sex, while the concentration of total BPs in urine was not significantly associated with age and sex. Enzymatic hydrolysis yielded a mean amplification of individual BPs concentrations in urine samples ranging from 1.8 times (BPA) to 4.6 times (BPS). Based on the outcomes, it was estimated that conjugated forms accounted for 96.9%, 96.2%, 94.7%, 94.1%, 92.6%, 89.1%, 87.3%, 87.2%, 87.1% and 85.8% of BPP, BPAF, BPZ, BPE, BPAP, BPF, BPA, BPC, BPS and BPF, respectively, in the pooled urine samples. Preliminary risk assessments indicated that the estimated daily intake of BPA was much higher than the latest proposed tolerable daily intake. Due to the unavailability of health-based guideline values for alternative BPs, some of them exhibit daily intakes comparable to BPA, implying that greater attention should be paid to health risks associated with exposure to BPs. [Display omitted] • Exposure to BPs was investigated in all age groups. • The proportion of conjugated forms of BPs in human urine was determined. • Described the relationship between BPs and their metabolites with gender and age. • Assessed the exposure risk of BPs in the general population. [ABSTRACT FROM AUTHOR]

Bisphenol analogues (BPs) are heavily used and negatively affect the health of human beings, however, there is little knowledge regarding human exposure to BPs other than BPA. This study aims to assess human exposure to BPs through investigating pooled urine and wastewater samples. Twenty-four pooled urine samples were prepared from 960 specimens (classified by age and gender). Wastewater samples were collected from six major wastewater treatment plants (WWTPs) in Guangzhou, South of China. BPA, BPS, and BPAF were widely detected in urine samples, with a median concentration of 0.96, 0.42, and 0.15 μg/L, respectively. Median urinary levels of BPA and BPS were higher in males than females (p > 0.05). In addition, BPA and BPS urinary levels in young adults (15–30 years old) were greater than those in children (0–15 years old) (p > 0.05). Nevertheless, most of the BPs were detected in wastewater samples, of which BPA and BPS were predominant BPs, with a median concentration of 1.0 and 0.29 μg/L. The average per capital mass loads of Σ BPs on the weekdays of mix typed WWTP was much higher than those of the weekends. Nonetheless, the average loads of Σ BPs on the weekdays of domestic WWTP was slightly lower than those of the weekends. This indicated that important sources of BPs might include industrial wastewater and household cleaning products. Urinary BPA, BPS, and BPAF accounted for less than 5% per capital mass loads in wastewater, suggesting that much of the BPA, BPS, and BPAF in municipal wastewater originate non-human excretion. Hence, the wastewater-based epidemiology (WBE) approach based on parent compounds is not available for assessing human exposure to BPs, neither for other industrial chemicals with diverse sources in municipal wastewater. These results contributes to the development of an efficient surveillance system which can provide insight in the trends of human exposure of BPs. [ABSTRACT FROM AUTHOR]