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[Objectives] This study was conducted to explore the quality control method and establish the quality standard of Zhuang medicine Buddlejae Flos. [Methods] The microscopic identification method was adopted to identify the characters and microscopic characteristics of dried Buddlejae Flos in combination with traditional experience. The moisture, ash, acid-insoluble components and extracts of Buddlejae Flos were determined with reference to general rules of Chinese Pharmacopoeia (2015 edition). TLC identification was performed. Liquid chromatography-mass spectrometry (LC-MS) was used to determine the contents of linarin and verbascoside in Buddlejae Flos, and gas chromatography-mass spectrometry (GC-MS) was adopted to detect pesticide residues in Buddlejae Flos. Heavy metal elements As, Cd and Pb were detected by inductively coupled plasma mass spectrometry (ICP-MS). [Results] The established method is simple and accurate. Clear spots were observed on the thin layer chromatograms, and the resolution was good. The average value of moisture content was 12.24%; the average value of ash content was 5.1%; the average value of acid-insoluble content was 7.5%; and the average value of extract content was 27.3%. The regression equation of rutin in Buddlejae Flos was y -11.896x -0. 004 9, R2 =0. 999 6, and the contents of linarin and verbascoside were 5 680 and 2 080 mg/kg, respectively. No pesticide residues and heavy metals were detected in the medicinal materials of Buddlejae Flos. [Conclusions] This study can provide reference for the quality standard control of Guangxi Zhuang medicine Buddlejae Flos. [ABSTRACT FROM AUTHOR]