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Objective To explore the relationship between the walking time of pregnant women and the maintenance of the antibody level of SARS-CoV-2 inactivated vaccine, so as to provide a reference basis for the prevention of pregnant women' s infection and the promotion of maternal and infant health during the normalization management of SARS-CoV-2 pneumonia epidemic. Methods In a multicenter cross-sectional study in Guangdong Province, 854 pregnant women who were vaccinated with inactivated SARS-CoV-2 vaccine were included to investigate their demographic characteristics and physical activity, and detect their serum SARS-CoV-2 antibody levels. Multifactor logistic regression model was used to analyze the correlation between the walking time of pregnant women and the positive rate of SARS-CoV-2 antibody. Results The positive rates of neutralizing antibody, IgG and IgM of serum SARS-CoV-2 were 44.6%, 46.1% and 3.4% respectively. There was a difference in the positive conversion rate of neutralizing antibodies to SARS-CoV-2 among pregnant women at different walking times (P <0.05), and this difference did not appear in the level of IgG and IgM antibodies (P >0.05). Compared to pregnant women who walked for more than 30 minutes per day, pregnant women who walked for 15-30 minutes per day had a higher NAb positivity rate (OR = 1.56, 95% CI: 1.09~2.23). Conclusion The walking time of pregnant women is related to maintaining the antibody level of SARS-CoV-2 vaccine. The antibody level of pregnant women who walk for 15~30min/d is higher. The walking exercise of pregnant women is beneficial to the immune system. It is suggested that pregnant women should exercise moderately every day to maintain good health. [ABSTRACT FROM AUTHOR]