1. The human prion gene M129V polymorphism is not associated with idiopathic Parkinson's disease in three distinct populations.
- Author
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Scholz SW, Xiromerisiou G, Fung HC, Eerola J, Hellström O, Papadimitriou A, Hadjigeorgiou GM, Tienari PJ, Fernandez HH, Mandel R, Okun MS, Gwinn-Hardy K, and Singleton AB
- Subjects
- Adult, Aged, Aged, 80 and over, Alleles, Codon, Creutzfeldt-Jakob Syndrome epidemiology, Creutzfeldt-Jakob Syndrome genetics, Female, Finland epidemiology, Gene Frequency, Genotype, Greece epidemiology, Humans, Male, Middle Aged, Polymorphism, Genetic physiology, United States epidemiology, Parkinson Disease epidemiology, Parkinson Disease genetics, Prion Diseases epidemiology, Prion Diseases genetics, Prions genetics
- Abstract
Coexistence of prion disease and idiopathic Parkinson's disease (IPD) has been previously described. It remains unclear whether this relationship may reflect the high incidence of IPD or whether both prion and IPD share common pathogenetic mechanisms. For this reason, we investigated the genotype distribution of the M129V polymorphism of the human prion gene for association with IPD (controls: n = 398, IPD cases: n = 400). No association between genotypes in codon 129 and IPD was detected in three distinct populations, suggesting that this PRNP polymorphism has no direct influence on the susceptibility to IPD.
- Published
- 2006
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