1. HIV-1 co-receptor CCR5 and CCR2 mutations among Greeks.
- Author
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Papa A, Papadimitriou E, Adwan G, Clewley JP, Malissiovas N, Ntoutsos I, Alexiou S, and Antoniadis A
- Subjects
- Alleles, Genotype, Greece, HIV Seronegativity genetics, Humans, Mutation, Receptors, CCR2, Gene Frequency, HIV Infections genetics, HIV-1 genetics, Receptors, CCR5 genetics, Receptors, Chemokine genetics, Receptors, HIV genetics
- Abstract
The frequency of CCR5 and CCR2 alleles in human immunodeficiency virus (HIV)-positive and HIV-negative populations of Northern Greece was investigated. The frequency of the CCR5Delta32 allele among the HIV-negative subjects was 0.052, while it was approximately two-fold lower among the seropositives, suggesting that the heterozygous genotype confers a partial resistance to the HIV infection. No significant difference in CCR2 allele frequency between the two groups was observed.
- Published
- 2000
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