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Simple Summary: The number of cancer patients who require an implantable electronic heart device due to their heart disease is steadily increasing. Radiotherapy is an important treatment option for esophageal cancer, in addition to surgery and chemotherapy. Ionizing radiation can lead to serious malfunctions of cardiac devices, including complete loss of function with life-threatening consequences. There is already data in the literature on other types of cancer and radiotherapy. Esophageal cancer is rare, so there is limited information on patients with this cancer who need radiotherapy and have an electronic heart device. We retrospectively analyzed the occurrence of cardiac device malfunction in patients with esophageal cancer in our study between 2012 and 2022. By applying our internal treatment protocol, serious cardiac device malfunctions during, and after radiotherapy could be prevented. It is important to carefully plan and select the energy of the photons. The manufacturer's recommended dose limits should be observed. (1) Background: The prevalence of cancer patients relying on cardiac implantable electronic device (CIED) is steadily rising. The aim of this study was to evaluate RT-related malfunctions of CIEDs. (2) Methods: We retrospectively analyze sixteen patients with esophageal cancer who were treated with radiotherapy between 2012 and 2022 at the University Hospital Heidelberg. All patients underwent systemic evaluation including pre-therapeutic cardiological examinations of the CIED functionality and after every single irradiation. (3) Results: Sixteen patients, predominantly male (14) with a mean age of 77 (range: 56–85) years were enrolled. All patients received 28 fractions of radiotherapy with a cumulative total dose 58.8 Gy. The mean maximum dose at the CIEDs was 1.8 Gy. Following radiotherapy and during the one-year post-radiation follow-up period, there were no registered events associated with the treatment in this evaluation. (4) Conclusion: The study did not observe any severe CIED malfunctions following each radiation fraction or after completion of RT. Strict selection of photon energy and alignment with manufacturer-recommended dose limits appear to be important. Our study showed no major differences in the measured values of the pacing threshold, sensing threshold and lead impedance after RT. [ABSTRACT FROM AUTHOR]

Simple Summary: Capsular contracture is one of the substantial complications of breast cancer patients undergoing post-mastectomy radiotherapy (PMRT) following an immediate implant-based breast reconstruction (IBR). Until now, there has been no therapeutic target to directly treat or manage capsular contracture, which emphasizes the importance of its prevention. A further assessment of risk factors and dosimetric characteristics is needed to minimize the risk and choose the optimal therapy approach. Our study aims to identify the risk factors and dosimetry characteristics associated with capsular contracture. Methods: We retrospectively analyzed 118 women with breast cancer who underwent PMRT following an IBR between 2010 and 2022. Patients were treated with PMRT of 50.0–50.4 Gy in 25–28 fractions. Capsular contracture was categorized according to the Baker Classification for Reconstructed Breasts. Results: After a median follow-up of 22 months, the incidence of clinically relevant capsular contracture (Baker III–IV) was 22.9%. Overall, capsular contracture (Baker I–IV) occurred in 56 patients (47.5%) after a median of 9 months after PMRT. The rate of reconstruction failure/implant loss was 25.4%. In the univariate analysis, postoperative complications (prolonged pain, prolonged wound healing, seroma and swelling) and regional nodal involvement were associated with higher rates of capsular contracture (p = 0.017, OR: 2.5, 95% CI: 1.2–5.3 and p = 0.031, respectively). None of the analyzed dosimetric factors or the implant position were associated with a higher risk for capsular contracture. Conclusion: Postoperative complications and regional nodal involvement were associated with an increased risk of capsular contracture following breast reconstruction and PMRT, while none of the analyzed dosimetric factors were linked to a higher incidence. Additional studies are needed to identify further potential risk factors. [ABSTRACT FROM AUTHOR]

Background: Instrumental musicians are a risk group for a variety of skin conditions., Objectives: To determine the frequency and risk factors of instrument-related skin disorders in musicians., Method: We mailed an 11-item survey to 19 German universities of music and performing arts., Results: 412 musicians returned the completed questionnaire, of whom 21.6% (89/412) had an instrument-related skin disorder including callosities (52/89; 58.4%), contact dermatitis (CD; 17/89; 19.1%), fiddler's neck (17/89; 19.1%), and erosion (3/89; 3.4%). Allergic CD (13/17; 76.5%) was most frequently reported in violinists and violists. Of 116 violinists and violists, 17 (14.7%) suffered from fiddler's neck. String and plucking instrumentalists most frequently reported callosities (61/89; 68.5%) and skin problems (32/37; 86.5%). Instrument-related skin disorders were significantly associated with high practice frequencies (P = 0.022) and a professional status (P = 0.001)., Conclusions: Callosities and CD were the most commonly reported skin changes in the respondents. Both callosities and skin problems such as CD and fiddler's neck are significantly associated with high practice frequencies and professional status. Our data indicate that among those returning the questionnaires, string players and plucking instrumentalists seem to be at highest risk of developing skin problems when compared with players of other musical instruments.