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Konservat‐Lagerstätten, such as the Toarcian (Early Jurassic) Posidonia Shale of southwestern Germany, are renowned for their spectacular fossils. Ichthyosaur skeletons recovered from this formation are frequently associated with soft tissues; however, the preserved material ranges from three‐dimensional, predominantly phosphatized structures to dark films of mainly organic matter. We examined soft‐tissue residues obtained from two ichthyosaur specimens using an integrated ultrastructural and geochemical approach. Our analyses revealed that the superficially‐looking 'films' in fact comprise sections of densely aggregated melanosome (pigment) organelles sandwiched between phosphatized layers containing fibrous microstructures. We interpret this distinct layering as representing condensed and incompletely degraded integument from both sides of the animal. When compared against previously documented ichthyosaur fossils, it becomes readily apparent that a range of preservational modes exists between presumed 'phosphatic' and 'carbonized' soft‐tissue remains. Some specimens show high structural fidelity (e.g. distinct integumentary layering), while others, including the fossils examined in this study, retain few original anatomical details. This diversity of soft‐tissue preservational modes among Posidonia Shale ichthyosaurs offers a unique opportunity to examine different biostratinomic, taphonomic and diagenetic variables that potentially could affect the process of fossilization. It is likely that soft‐tissue preservation in the Posidonia Shale was regulated by a multitude of factors, including decay efficiency and speed of phosphatic mineral nucleation; these in turn were governed by a seafloor with sustained microbial mat activity fuelled by high organic matter input and seasonally fluctuating oxygen levels. [ABSTRACT FROM AUTHOR]

Objectives: To investigate the correlation between soft- and hard-tissue changes after mandibular orthognathic surgery, to generate precise prognostic values for the esthetic treatment outcome of the facial profile.Material and Methods: In this retrospective study, sagittal changes in the facial soft tissue profile in relation to surgical changes in hard structures after mandibular osteotomy were examined. The sample population included 144 reported adult patients aged 17-50 years who had received combined mandibular orthognathic surgery and orthodontic treatment at the Department of Orthodontics, Ludwig-Maximilians University of Munich, Germany. Both mandibular advancement and mandibular setback cases in monognathic and bignathic osteotomy procedures were included. All subjects had undergone rigid fixation. A cephalometric analysis of presurgical and postsurgical cephalograms was performed, and the correlations between hard-tissue and soft-tissue change ratios were evaluated using a bivariate linear regression analysis.Results: The lower lip, represented by the landmark Labrale inferius (Li), followed the lower incisor (Ii) by 77%. The soft-tissue B-point (B') followed the B-point (B) by 97% and the soft-tissue Pogonion (Pg') followed the Pogonion (Pg) by 97% in a linear correlation.Conclusion: The scatterplots show a distinct linear correlation and no significant difference in the direction of the movement. A wider spread for the lower lip (Li/Ii) indicates a lower predictability of the expected lip position, whereas a narrow spread of the chin values (B'/B and the Pg'/Pg) reveals a very good predictability of the postoperative chin position.Clinical relevance: This study contributes valid data for the soft-tissue profile prediction in orthognathic surgery. [ABSTRACT FROM AUTHOR]

Background: Open fractures are orthopaedic emergencies that carry a high risk for infection, non-union and soft tissue complications. Evidence-based treatment is impeded by the lack of high-quality evidence-based studies. The aim of this investigation was to elucidate the current practice of open fracture management in Germany and to determine major differences in treatment.Methods: Surgeons were asked to complete an online questionnaire consisting of 45 items developed by an expert consensus. The first part covered questions on general principles of open fracture management. The second part included questions on soft tissue management, the preferred method of initial surgical stabilisation, microbiological testing, employment of pulsatile lavage and local antibiotics, antibiotic regimen, second-look operations, and blood testing.Results: Of 653 respondents, 364 (65 %) completed the first part and 314 (48 %) completed the second part of the online survey. 55 % answered that a standard operating procedure for the diagnosis and treatment of patients with open fractures exists in their hospital. Only 25 % leave pre-hospitalisation applied dressings intact until arrival of the patient in the operating room, and 40 % make this decision depending on information provided by pre-hospitalisation emergency personnel. 84 % participants exclude the use of antibiotic-coated implants in the treatment of open fractures. The favoured stabilisation method in Gustilo type I fractures is definitive internal osteosynthesis and primary wound closure for 61 % of respondents. In Gustilo type II (74 %) and type III fractures (93 %), temporary external fixation is preferred. High-pressure pulsatile lavage is used by 22 % responding surgeons in Gustilo type I fractures, 53 % for type II fractures and 67 % for type III fractures.Conclusions: Open fracture management differs considerably among surgeons in Germany. Further studies are needed to deliver high-quality evidence concerning primary fracture stabilisation, soft tissue management and second-look operations. Existing evidence-based recommendations for general treatment, antibiotic prophylaxis and soft tissue management should be followed more strictly in clinical practice. [ABSTRACT FROM AUTHOR]

Background/aim: The aim of this study was the conception, production, material analysis and cytocompatibility analysis of a new collagen foam for medical applications., Materials and Methods: After the innovative production of various collagen sponges from bovine sources, the foams were analyzed ex vivo in terms of their structure (including pore size) and in vitro in terms of cytocompatibility according to EN ISO 10993-5/-12. In vitro, the collagen foams were compared with the established soft and hard tissue materials cerabone and Jason membrane (both botiss biomaterials GmbH, Zossen, Germany)., Results: Collagen foams with different compositions were successfully produced from bovine sources. Ex vivo, the foams showed a stable and long-lasting primary structure quality with a bubble area of 1,000 to 2,000 μm 2 In vitro, all foams showed sufficient cytocompatibility., Conclusion: Collagen sponges represent a promising material for hard and soft tissue regeneration. Future studies could focus on integrating and investigating different additives in the foams., (Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)