1. Association of changes in inflammation with variation in glycaemia, insulin resistance and secretion based on the KORA study.
- Author
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de Las Heras Gala T, Herder C, Rutters F, Carstensen-Kirberg M, Huth C, Stehouwer CDA, Nijpels G, Schalkwijk C, Flyvbjerg A, Franks PW, Dekker J, Meisinger C, Koenig W, Roden M, Rathmann W, Peters A, and Thorand B
- Subjects
- Adult, Aged, Cross-Sectional Studies, Female, Germany, Humans, Inflammation metabolism, Longitudinal Studies, Male, Middle Aged, Blood Glucose metabolism, Diabetes Mellitus, Type 2 complications, Diabetes Mellitus, Type 2 metabolism, Inflammation complications, Insulin metabolism, Insulin Resistance
- Abstract
Aims: Subclinical systemic inflammation may contribute to the development of type 2 diabetes, but its association with early progression of glycaemic deterioration in persons without diabetes has not been fully investigated. Our primary aim was to assess longitudinal associations of changes in pro-inflammatory (leukocytes, high-sensitivity C-reactive protein (hsCRP)) and anti-inflammatory (adiponectin) markers with changes in markers that assessed glycaemia, insulin resistance, and secretion (HbA
1c , HOMA-IR, and HOMA-ß). Furthermore, we aimed to directly compare longitudinal with cross-sectional associations., Materials and Methods: This study includes 819 initially nondiabetic individuals with repeated measurements from the Cooperative Health Research in the Region of Augsburg (KORA) S4/F4 cohort study (median follow-up: 7.1 years). Longitudinal and cross-sectional associations were simultaneously examined using linear mixed growth models. Changes in markers of inflammation were used as independent and changes in markers of glycaemia/insulin resistance/insulin secretion as dependent variables. Models were adjusted for age, sex, major lifestyle and metabolic risk factors for diabetes using time-varying variables in the final model., Results: Changes of leukocyte count were positively associated with changes in HbA1c and HOMA-ß while changes in adiponectin were inversely associated with changes in HbA1c . All examined cross-sectional associations were statistically significant; they were generally stronger and mostly directionally consistent to the longitudinal association estimates., Conclusions: Adverse changes in low-grade systemic inflammation go along with glycaemic deterioration and increased insulin secretion independently of changes in other risk factors, suggesting that low-grade inflammation may contribute to the development of hyperglycaemia and a compensatory increase in insulin secretion., (© 2018 John Wiley & Sons, Ltd.)- Published
- 2018
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