1. [Understanding and reducing the risk of adverse drug reactions in pediatric patients].
- Author
-
Gotta V, van den Anker J, and Pfister M
- Subjects
- Adolescent, Child, Child, Preschool, Female, Germany, Humans, Inappropriate Prescribing legislation & jurisprudence, Infant, Infant, Newborn, Male, Mandatory Reporting, Pharmacovigilance, Risk Assessment methods, Adverse Drug Reaction Reporting Systems legislation & jurisprudence, Drug-Related Side Effects and Adverse Reactions diagnosis, Drug-Related Side Effects and Adverse Reactions prevention & control, Inappropriate Prescribing prevention & control, Medication Errors prevention & control, Pediatrics legislation & jurisprudence
- Abstract
Developmental pharmacology influences the safety profile of drugs in pediatrics. Altered pharmacokinetics and/ or pharmacodynamics of drugs make pediatric patients susceptible to adverse drug reactions (ADRs), especially infants and newborns. Since the efficacy/ safety balance of most available drugs has not been formally evaluated in pediatric clinical trials, optimal dosing is rarely known in pediatrics. Suboptimal pediatric drug formulations make dose optimization even more difficult exposing pediatric patients to medication errors like overdosing and associated ADRs. We provide an overview of pediatric ADRs and discuss recent regulatory and pharmacological measures to understand and reduce risk of ADRs in pediatric patients.
- Published
- 2015
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