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A recent study conducted by researchers at the University of Freiburg in Germany has provided new data on Alzheimer's disease. The study focused on the role of nuclear pore complexes (NPCs) in neurodegeneration. Specifically, the researchers investigated the role of the translocated promoter region (Tpr) in adult neural stem/precursor cells (NSPCs) in Alzheimer's disease. They found that altered levels and subcellular localization of Tpr in the central nervous system (CNS) can affect Tpr functionality, which in turn regulates the architecture and number of NSPC NPCs, potentially leading to aberrant neurogenesis. This research provides valuable insights into the mechanisms underlying Alzheimer's disease and may contribute to the development of new therapeutic approaches. [Extracted from the article]