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Objective: Educational track choices have far-reaching consequences because they are associated with long-term life success. Theoretical approaches and previous empirical research have nearly exclusively identified family background and achievement as determinants of these choices. Although students' educational track choices might fit their personality, individual differences in personality have not been explored. We investigated the effects of two personality aspects-RIASEC interests and Big Five traits-on hierarchically ranked track choices (vocational vs. general educational track), alongside family background and achievement., Method: We used two German data sets (TOSCA 10 study: N = 473; TOSCA study: N = 4,218) focusing on choices between the general educational track (leading to higher educational attainment) and the vocational track (leading to work life) at two different stages in educational careers. We ran several multiple (logistic) regressions., Results: The results showed that certain aspects of students' personality matter for educational track choices. Accordingly, across both studies, students with high Investigative or Enterprising interests more often chose the general educational track, whereas students with high Social or Conventional interests more often chose the vocational track-after the Big Five personality traits, achievement, and family background were controlled for. The Big Five traits showed no or only small significant associations with educational track choices., Conclusion: These findings underscore the importance of considering individual differences when investigating important life outcomes such as track choices., (© 2020 The Authors. Journal of Personality published by Wiley Periodicals LLC.)

Atopic dermatitis is a common inflammatory skin disease with a strong heritable component. Pathogenetic models consider keratinocyte differentiation defects and immune alterations as scaffolds, and recent data indicate a role for autoreactivity in at least a subgroup of patients. FLG (encoding filaggrin) has been identified as a major locus causing skin barrier deficiency. To better define risk variants and identify additional susceptibility loci, we densely genotyped 2,425 German individuals with atopic dermatitis (cases) and 5,449 controls using the Immunochip array followed by replication in 7,196 cases and 15,480 controls from Germany, Ireland, Japan and China. We identified four new susceptibility loci for atopic dermatitis and replicated previous associations. This brings the number of atopic dermatitis risk loci reported in individuals of European ancestry to 11. We estimate that these susceptibility loci together account for 14.4% of the heritability for atopic dermatitis.