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1. VIM-15 and VIM-16, two new VIM-2-like metallo-beta-lactamases in Pseudomonas aeruginosa isolates from Bulgaria and Germany.

Author

Schneider I, Keuleyan E, Rasshofer R, Markovska R, Queenan AM, and Bauernfeind A

Subjects
Amino Acid Substitution, Bacterial Proteins genetics, Bulgaria, Catalysis, Germany, Hydrolysis, Isoenzymes genetics, Isoenzymes metabolism, Kinetics, Microbial Sensitivity Tests, Molecular Sequence Data, Sequence Analysis, DNA, beta-Lactamases genetics, Bacterial Proteins metabolism, Pseudomonas aeruginosa enzymology, Pseudomonas aeruginosa isolation & purification, beta-Lactamases metabolism
Abstract

Two Pseudomonas aeruginosa urine isolates from Bulgaria and Germany produced two new VIM-2 variants. VIM-15 had one amino acid substitution (Tyr218Phe) which caused a significant increase in hydrolytic efficiency. The substitution Ser54Leu, characterizing VIM-16, showed no influence on enzyme activity. Both genes were part of class I integrons located in the chromosome.

Published
2008
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