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The cognitive advantage (CA) hypothesis claims that multilingualism promotes the development of several basic cognitive capacities. A large number of empirical findings support this hypothesis, but recently there have also been numerous contradictory findings and methodological objections. The present paper extends the investigation of possible cognitive advantages from basic cognitive (executive) functions to broader cognitive competencies such as cognitive flexibility. A promising candidate for this is 'flexibility of goal adjustment' (FGA), a capacity of developmental regulation that solves problems through flexible adaptation processes. In a study with N = 119 monolingual and multilingual adults we found the predicted positive correlation between multilingualism and FGA. However, the mediator function of executive capacities entailed in the CA hypothesis operationalised as Stroop and flanker tasks could not be demonstrated.

Purpose: A previous study about a long-term internship implemented in the Master's program of eleven physical education preservice teachers showed that the preservice teachers had low performance scores in the area of Instructional Support. These results left many questions unanswered, so the written self-reflections of the preservice teachers were investigated. Method and Results: A quantitative content analysis of their written reflections, based on the dimensions of the Classroom Assessment Scoring System K-3, showed that the participants pay little attention to the domain of Instructional Support. A qualitative content analysis showed that the preservice teachers relied on self-made experiences and the advice given by their mentors from school who pay little attention to Instructional Support. Discussion and Conclusion: Instructional Support should be given a higher priority in the context of long-term internships and in accompanying reflective assignments, especially with regard to differentiation and inclusion of all students.

Economic inequality has been consistently rising in recent decades in many Western countries including Germany. This is a pressing issue as greater economic inequality within a society has detrimental consequences for well-being, social stability, productivity, and even life expectancy. However, little is known about how individuals of different ages experience and respond to social inequality across adulthood. Because status differences are perceived as more malleable in young adulthood (i.e., young adults can expect to move up the social ladder) and only manifest across adulthood, we predicted that negative emotional reactions to the perceived standing in the social hierarchy should become increasingly pronounced with age. Consistently, a first study based on a national representative sample in Germany (N = 2,542; 18-91 years) confirmed that subjective social status had a much stronger effect on the acceptance of social inequality among middle-aged and older, as compared with younger, adults. In a second experimental study (N = 387; 18-89 years), participants of any age responded with negative emotional reactions when rising inequality was made salient. However, subjective social status moderated this effect only in middle-aged and older, but not younger, adults. Finally, a third experimental study (N = 605; 18-82 years) showed that, compared with middle-aged and older adults, younger adults maintained stronger upward mobility beliefs that accounted for the age-differential effects of subjective social status on negative emotional reactivity to rising inequality. We discuss the central role of upward mobility beliefs for individuals' responses to social inequality across the adult life span.

Coping research has consistently shown that accommodative coping is positively correlated with individuals' health. Until now, however, there have been little to no studies on the prognostic impact of accommodative coping on health, and only a few studies investigating its buffering effect on the relation between stress and health in childhood and adolescence. Thus, two main research questions were tracked in two longitudinal studies: Study 1 investigated if accommodative coping is indeed a functional resource that longitudinally predicts well-being in a sample of N = 403 adolescents (aged 12-15 years at Wave 1). Study 2 examined the function of accommodative coping under stressful conditions by investigating its buffering effect on the negative impact of school-related stress on well-being in a sample of N = 86 children (aged 9-12 years at Wave 1). Study 1 revealed accommodative coping longitudinally predicting well-being, and, conversely, there was no prediction of well-being through accommodative coping over time. Study 2 revealed a significant moderating effect and gives a first indication that accommodative coping buffers the negative impact of school-related stress on well-being in childhood. The results indicate that accommodation is a functional coping resource in adolescence that diminishes the negative impact of specific stressors. All main and further results are discussed, and implications for further research are given.

Former coal mines hosted in Upper Carboniferous silt- and sandstones in the Ruhr Basin, NW Germany, are currently examined for post-mining applications (e.g. geothermal energy) and are also important tight-gas reservoir analogs. Core material from well Pelkum-1, comprising Westphalian A (Bashkirian) delta deposits, was studied. The sandstones and siltstones are generally tight (mean porosity 5.5%; mean permeability 0.26 mD). Poor reservoir properties primarily result from pronounced mechanical compaction (mean COPL 38.8%) due to deep burial and high contents of ductile rock fragments. Better reservoir properties in sandstones (>8%; >0.01 mD) are due to (1) lower volumes of ductile grains (<38%) that deform during mechanical compaction and (2) higher volumes in feldspar and unstable rock fragments. During burial these form secondary porosity (>1.5%) resulting from acidic pore water from organic matter maturation. Still, sandstones with enhanced porosities only show a small increase in permeability since authigenic clays (i.e. kaolinite and illite) or late diagenetic carbonates (i.e. siderite and ferroan dolomite/ankerite) clog secondary porosity. Quartz cementation has a minor impact on reservoir properties. Evaluating the Si/Al ratio can be a suitable proxy to assess grain sizes and may be a convenient tool for further exploration. Supplementary material: Lithologs and petrophysical data of well Pelkum-1 are available at https://doi.org/10.6084/m9.figshare.c.7003156 [ABSTRACT FROM AUTHOR]

Background: Demographic development in rural and urban areas differs substantially. Demographics and access to specialized head and neck cancer centers may affect head and neck cancer patients' (HNCP) outcomes. Here, we compare epidemiological indicators and outcomes of HNCP in rural and urban Germany. Patients and Methods: In a retrospective analysis of data from the Center for Cancer Registry Data (ZfKD) between 2002 and 2017, 212,920 HNCP were included. Incidence, demographics, travel distance to specialized centers, and ground values were compared between rural and urban areas with a focus on their association with patient outcomes. Results: The mean age of HNCP was significantly higher in urban areas (mean difference = 1.4 years; p < 0.0001), but increased at a comparable rate (p = 0.26) in rural and urban areas during the observation period. Gender imbalance was higher in rural areas (mean ratio of men/women: 4.1 vs. 3.1; p < 0.0001), but showed a comparable trend toward equilibration in both, rural and urban districts (p = 0.46). The portion of HNCP of the entire HNCP population living in urban areas increased from 55.9% in the year 2002 to 76.4% in the year 2017. There was no significant difference or change in the ratio of advanced to low UICC stage during the observation period (p = 0.26). However, travel distances to medical centers were higher in rural areas, especially (p < 0.0001) in East Germany. Median survival of HNCP in rural areas was significantly lower than in urban areas (42 months [SEM = 0.7; CI: 40.5–43.5] vs. 54 months [SEM = 1.2; CI: 51.7–56.3]; p < 0.0001) in East Germany, whereas in West Germany no significant difference was observed (59 months [SEM = 0.8; CI: 57.4–60.6] vs. 60 months [SEM = 0.5; CI: 59.0–61.0]; p = 0.15). Conclusions: Place of residence contributes to survival outcome of HNCP. Access to specialized care and socioeconomic factors could be improved in East Germany. [ABSTRACT FROM AUTHOR]

We investigate how self-employment in East Germany was impacted by 40 years of Soviet-style communism and the subsequent shock transition to a market economic system. To this end, we compare self-employment in East and West Germany after reunification with self-employment before the separation of Germany after World War II. Our results show that the strict anti-entrepreneurial policies prevalent during the Soviet regime do not have a long-run negative effect on self-employment in East Germany. Quite to the contrary, self-employment in East Germany today is higher than before German separation. This finding cannot be explained by necessity self-employment. Our analysis suggests that current differences in self-employment between East and West Germany are pre-dominantly a result of the sudden shock transformation that occurred with reunification, rather than the outcome of four decades of anti-entrepreneurial policies and ideology. [ABSTRACT FROM AUTHOR]

In a cross-sectional study with 541 German students (mean age: 12.61 yrs) and (for a subsample of N = 350) one of their parents, developmental conditions for a particular resource of self-regulation ("Flexibility of Goal Adjustment"; Brandtstadter & Renner, 1990) are investigated. Theoretical ¨ arguments and empirical results from related fields suggested in particular two sets of variables as possible predictors of adolescents' adaptive competencies. Individual aspects (students' cognitive capacities and earlier developmental stimulations) as well as external conditions (parental coping competences and parent-youth-coorientation) were assessed and included into a path model. Results suggest that both the parental variables and particular cognitive resources contribute directly to adolescents' adaptive resources, whereas earlier developmental stimulations influenced adolescents' adaptive resources in an indirect way. Suggestions for further studies were discussed with respect both to theoretical and methodological aspects.

What characterizes regions where right‐wing populist parties are relatively successful? A prominent hypothesis proposed in the emerging "geography of discontent" literature claims that places that are "left behind" constitute a breeding ground for the rise of populism. We re‐examine this hypothesis by analyzing the rise of populism in Germany. Our results suggest that high vote shares of populist parties are associated with the long‐term decline of a region's relative welfare, which goes beyond a lifespan of people inhabiting such "left behind" places. Moreover, we are able to show that a place‐based collective memory about past prosperity plays a crucial role in shaping present resentment. Finally, we find the education level of the regional population to be an important channel through which the collective memory about the past translates into populism support today. [ABSTRACT FROM AUTHOR]

The Ruhr Basin in Germany is one of the most extensively studied 3D rock volumes due to subsurface coal mining over the past centuries. With the final closure of the last coalfield in 2018, mine flooding was initiated and may result in induced ground movements. However, abandoned coal mines also provide the possibility for post-mining geothermal utilisation. To improve the understanding of rock properties with respect to flow properties and heat flux in the Ruhr Basin, three drill cores of clastic sedimentary rocks of the Westphalian A (Langsettian) and Westphalian B (Duckmantian) were characterised and the facies analysed. The studied 270 m core material show 4th order sequences of coarsening- and fining-upward cycles in an overall shallowing upward trend. Up to 17 m thick sandstone beds are associated with the delta front, mudstones and siltstones are related to the lower delta plain and up to 4 m thick coal seams linked to wetlands of the lower delta plain. Rock properties show low compressional velocities with a minimum of 2,886 m/s in sandstones of the delta front, which are negatively correlated with porosities of up to 15.6%. Likewise, porosity is a major control on thermal conductivity with a minimum of 2.3 W/(m×K) for high porosity sandstones. For less porous samples, thermal conductivity becomes less dependent on porosity but more strongly on mineralogy. Comparing our results with accessible thermal conductivity data from North Rhine-Westphalia (NRW), the high values of up to 5.3 W/(m×K) seem promising for potential geothermal applications. Furthermore, the results of this study imply that the classification based on facies associations is less suitable than the classification based on grain sizes in order to assess the geothermal potential. Overall, the Upper Carboniferous (Pennsylvanian) samples of this study show low porosity (mean 5.6%) and permeability (mean 0.1 mD). Thus fluid flow during mine flooding and potential future geothermal applications will primarily rely on permeable faults and fracture systems around the abandoned mine galleries as well as the galleries themselves. [ABSTRACT FROM AUTHOR]

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Purpose: Cancer patients have to overcome various barriers to obtain diagnostics and treatment at head and neck cancer centers. Travel distance to a specialized hospital may result in psychosocial and financial distress, thus interfering with diagnostics, treatment, and follow-up care. In this study, we have aimed to analyze the association of travel distance with cTNM status, UICC stage at primary diagnosis, and survival outcomes of head and neck cancer (HNC) patients. Methods: We have analyzed data of 1921 consecutive HNC patients diagnosed between 2014 and 2019 at the head and neck cancer center of the Comprehensive Cancer Center Ulm (CCCU), Germany. Postal code-based travel distance calculation in kilometers, TNM status, and UICC stage were recorded at initial diagnosis. The assembly of travel distance-related groups (short, intermediate, long-distance) has been investigated. Moreover, group-related survival and recurrence analysis have been performed. Results: In contrast to observations from overseas, no association of travel distance and higher cTNM status or UICC stage at primary diagnosis has been observed. Furthermore, no significant differences for recurrence-free survival and overall survival by travel distance were detected. Conclusion: In southern Germany, travel distance to head and neck cancer centers seems to be tolerable. Travel burden is not synonymous with travel distance alone but also involves sociodemographic, monetary, and disease-specific aspects as well as accessibility to proper infrastructure of transport and health care system. [ABSTRACT FROM AUTHOR]

The aim of this study was to investigate whether pH is stable when transporting ovarian tissue in media buffered with either HEPES or histidine. Furthermore, if the choice of transport media impacts the in vitro maturation rate of oocytes collected in connection with ovarian tissue cryopreservation. Human ovaries (n = 34) collected for ovarian tissue cryopreservation were transported immersed in either 30 ml of HEPES buffered (follicle flushing media (Origio; Denmark)) or histidine buffered media (Custodiol®-HTK, Koehler-Chemie, Germany). Tissue was transported on ice for 4–5 h. At arrival, the ovary was weighed, and the pH of the media was measured at 0 °C. From 15 patients, immature oocytes were collected for in vitro maturation, oocytes that matured to metaphase II were evaluated. The pH measured in the HEPES buffered media (pH = 7.5 ± 0.13, n = 18) was significantly higher (p < 0.001) than the pH measured in the histidine buffered media (pH = 7.2 ± 0.05, n = 16). The standard deviation of pH measurements for the histidine buffered media was significantly lower than for the HEPES buffered media measurements (p < 0.0001). A total of 170 and 247 immature oocytes were collected and in vitro matured from ovaries transported in HEPES and histidine buffered media, respectively. The maturation rate of immature oocytes after IVM was similar in the two groups. The results show that pH in the histidine buffered media is closer to the physiological level and more stable than in HEPES buffered medium and support the use of histidine buffered media for cooled transportation of human ovaries. [ABSTRACT FROM AUTHOR]

In crossover mixed analyses, one form of data is analyzed applying techniques that usually are associated with the alternative paradigm in order to yield a higher level of data integration. This basic principle is implemented in equalstatus studies and in quantitative-as well as in qualitativedominated approaches. Focusing on the latter, data conversion has been a vital issue of mixed methods research for many years, likely because it entails quantitizing narrative data to provide a basis for descriptive and inferential statistical analyses. Referring hereon, this article presents a qualitative-dominated crossover mixed methods study dealing with the problem of honorary work in German sports clubs, an issue that has been intensively discussed in sports and in other areas of society due to some alarming developments in social life. In this process, the issue of honorary work is utilized as an example of demonstrating a methodology. The design presented in this article involved use of a crossover analysis that converts narrative data into numerical data and involves analysis of the new data set using multiple correspondence analysis (MCA) with the aim of discovering patterns among the multidimensional data. In turn, these patterns are interpreted against the background of the first qualitative strand to enhance our understanding. Thus, this study is to be referred to as qualitative-dominated because the sets of qualitative analyses are more comprehensive and important and the researchers have taken a stance that is constructivist, while concurrently believing that quantitative data adds value to this approach. [ABSTRACT FROM AUTHOR]

Background: The community-based mental health care programme GBV is based on the British Community Mental Health Teams and the Dutch Flexible Assertive Community Treatment model. In addition, the programme offers crisis-intervention services. A special feature of this integrated care programme is the initial standardised assessment process regarding empowerment, unmet care needs, and psychosocial functioning, used to verify the need for such a comprehensive form of care. The project evaluates the assessment process and analyses the effectiveness and cost-effectiveness of GBV compared to treatment as usual.Methods: This randomised, controlled study includes five assessments over 2 years. In twelve regions in Germany, 1000 patients with severely impaired psychosocial functioning and unmet care needs will be recruited. Study eligibility relies on an indication for GBV based on the results of the initial assessment. The primary outcome is improved self-reported empowerment. Further outcomes include improved treatment satisfaction and subjective quality of life, reductions in patients' unmet needs and illness-related clinical and social impairment, and an improved cost-effectiveness ratio of the resources used (from the perspectives of both statutory health insurance and the national economy). In addition, the GBV's effects on the burden and quality of life of informal caregivers of patients will be investigated.Discussion: The study's results are expected to provide information on whether the community-based mental health care programme GBV contributes to improving mental health care provision in Germany. In addition, the study will show whether the GBV successfully overcomes the weaknesses that former research has identified regarding a German integrated care programme. Such improvement is particularly expected with respect to the semi-structured assessment within GBV.Trial Registration: German Clinical Trial Register, DRKS00019086 . Registered on 3 January 2020. [ABSTRACT FROM AUTHOR]

Background: Blood or plasma samples from rural areas are often transported under suboptimal conditions to central laboratories. The negative influence of different storage temperatures during transportation as well as long transportation times on the stability of unprotected HIV RNA is well known. Therefore, the correct and reliable quantification of HIV RNA might be very difficult. A stabilization solution for the storage and transportation of plasma samples was developed which stabilizes RNA for seven days up to 45°C without viral load changes. Methods: Blood samples from HIV positive individuals were collected into EDTA containing tubes. The isolated plasma samples in Germany were pipetted into pre-prepared RNA stabilization tubes and incubated for seven days at 45°C. HIV-1 RNA quantification was performed on a HIV-1 LCx m 2000 system from Abbott and a Qiagen/ Artus HI Virus-1 RG RT-PCR Kit on a Rotor-Gene Q PCR machine. In addition, plasma samples were collected and tested using existing SOP for storage and transportation in Nigeria. Plasma samples were treated with and without stabilization solution and the AMPLICOR HIV-1 MONITORTM test was used to determine viral load. Results: Seventy-four stabilized plasma samples were tested in Germany and results were compared to those tested unprotected within two hours. No significant changes of viral load were detected up to seven days and 45°C in case of stabilized samples. In contrast RNA of the same unprotected samples was no longer detectable after one day at 45°C. Additionally, 22 plasma samples were investigated on day zero and under field conditions in Nigeria without changes of the viral load after seven days under given temperature conditions. Conclusions: No cooling chain is necessary for the storage and/or transportation of plasma samples treated with the new RNA stabilization solution for up to seven days. The use of this solution to preserve plasma RNA will be very helpful in countries where the environmental temperature is higher than 30°C, thus addressing the problem of unreliable viral load results due to suboptimal storage or transportation conditions. Further, the costs of storage and transportation of samples for viral load quantification could be significantly reduced. [ABSTRACT FROM AUTHOR]

This paper considers Habermas' model of a post‐secular political order in the light of the debate on male circumcision that arose in Germany after a court ruled that male circumcision was an unjustifiable act of bodily harm. Central to this model is the idea that religious reasons can only become effective in central legal institutions when they are translated into secular reasons. My paper demonstrates that there are two distinguishable readings of this proviso. On the one hand, there is a broad reading according to which it is only necessary to reach a conclusion that is in line with the democratic principle stating that all citizens can be regarded as co‐legislators even if non‐generalizable value orientations might then shape the interpretation of fundamental rights (in the case of circumcision, the right to bodily integrity). On the other hand, a truly secular (narrow) reading would avoid the inclusion of non‐generalizable value orientations. The debate on circumcision demonstrates that these two interpretations lead to different and conflicting modes of justification. The broad reading allows for a justification of male circumcision, whereas the narrow reading makes such a justification unlikely. In addition, the filtering function of the proviso is weakened in a broad reading. [ABSTRACT FROM AUTHOR]

This study aimed to provide further insight into the question of why older adults show a higher precautionary behaviour regarding crime (behavioural fear), although they do not estimate their victimisation risk as higher than young adults and they do not experience fear more often. In two cross-sectional studies, the hypothesis was tested that the age-related increase in precautionary behaviour is an expression of higher dispositional fear with age. The vignette technique was employed to induce situational fear of crime across various situations as a proxy for dispositional fear. In contrast to the hypothesis, in Study 1 (young: 18-30 years, N = 179 vs. middle-aged: 50-64 years, N = 106), only younger adults reported higher situational fear in two vignettes. In Study 2 (young: 18-30 years, N = 129 vs. young-old: 65-84 years, N = 114), younger adults indicated higher situational fear again; however, young-old adults reported higher situational fear in other vignettes. The findings suggest that there is no general increase in the intensity of situational fear of crime with age and thus no age-related change in dispositional fear. Moreover, situational fear did not serve as mediator in the relationship between age and precautionary behaviour. Alternative accounts for the increase in behavioural fear of crime are discussed as well as emotion regulation mechanisms in response to the induction method. [ABSTRACT FROM AUTHOR]

The article discusses a court case pertaining to gatherings of people on airport property in which a constitutional complaint was lodged against the security workers of the Frankfurt, Germany airport for removing demonstrators in August of 2006. The author offers information on the German legal code which apply to groups gathered on publicly-owned property, examines the legal basis upon which the protesters were removed, and describes the civil rights requirements of the chosen legal solution.

The new third-generation synchrotron radiation source PETRA III located at the Deutsches Elektronen-Synchrotron DESY in Hamburg, Germany, has been operational since the second half of 2009. PETRA III is designed to deliver hard X-ray beams with very high brilliance. As one of the first beamlines of PETRA III the high-resolution diffraction beamline P08 is fully operational. P08 is specialized in X-ray scattering and diffraction experiments on solids and liquids where extreme high resolution in reciprocal space is required. The resolving power results in the high-quality PETRA III beam and unique optical elements such as a large-offset monochromator and beryllium lens changers. A high-precision six-circle diffractometer for solid samples and a specially designed liquid diffractometer are installed in the experimental hutch. Regular users have been accepted since summer 2010. [ABSTRACT FROM AUTHOR]

We compiled homogeneous long-term time series comprising 39 variables representing the German Bight and for the period 1975–2004. A diverse set of variables was selected to cover multiple trophic levels and different environmental forcing thus to examine long-term changes in this coastal region. Previous studies have hypothesised the presence of regime shifts in observations extending over the entire North Sea. Focusing on a smaller spatial scale, and closer to the coast, we investigated the major modes of variability in the compiled time series using principal component analysis. The results obtained confirm a previously identified regime shift in the North Sea in 1987/1988 and suggest that the German Bight is dominantly characterised by long-term modes of variability. In the German Bight, the shift of 1987/1988 is driven primarily by temperature, Gulf Stream index, frost days and Secchi depth. Changes in some of the ecosystem variables (plankton and fish) appear to be related to changes in these driving variables. In particular, we documented strong positive correlations between the long-term trend showed by the first principal component and herring, Noctiluca scintillans, and, to a lesser extent, Pleurobrachia pileus. Two gadoids, namely cod and saithe, showed negative correlations with the observed long-term mode of variability. Changes in the sum of five small calanoid copepods were, however, less marked. Phosphate and ammonium exhibited a decreasing trend over the last 30 years. Diatoms and Calanus helgolandicus did not show evidence of changes in concert to this trend. Specific analyses of the data divided into three different subsets (biological, climatic and chemical) characterise the climate of the German Bight as highly dynamic also on short timescales (a few years) as compared to much smoother biological and chemical components. The dynamic regime of the German Bight taken together with a low correlation between the major mode of variability and phytoplankton and zooplankton data suggests that the lower trophic levels of this ecosystem are remarkably resilient. [ABSTRACT FROM AUTHOR]

Polymorphisms in the CTLA4 gene region have been associated with susceptibility to autoimmune diseases. The recently described single nucleotide polymorphism CT60, located in the 3′ untranslated region of CTLA4 is associated with Graves' disease, thyroiditis, autoimmune diabetes and other autoimmune diseases. A case-control association study was conducted in German, Hungarian and Polish multiple sclerosis (MS) patients and regional control individuals for the CTLA4 CT60 and +49A/G polymorphisms. No significant association of these polymorphisms or respective haplotypes with MS was found. No association of CT60 genotypes with T cell expression of ICOS and CTLA-4 after in vitro stimulation was detected. [ABSTRACT FROM AUTHOR]

Meso- and macrozooplankton have been sampled in the German Bight since 1974. Inter-annual changes in the dynamics of selected species have been analysed in terms of mean annual abundance and timing of abundance maxima. Information on new immigrants is also presented. Possible causes of the observed changes, particularly in relation to nutrient availability and climatic signals, are discussed. [ABSTRACT FROM PUBLISHER]

Simple Summary: We detected an increase in the mean age at diagnosis among 2450 patients with head and neck carcinoma diagnosed between 2004 and 2018 in the head and neck cancer center Ulm (Germany) in comparison to the mean age in the general population of the main catchment area. Carcinoma incidences were rising too. The steepest ascent in incidence rates was found in the age group >70 years of age. These results indicate that health care providers need to prepare for an increasingly older group of cancer patients. This study is the first step to a nationwide analysis among German patients. Background: The impact of demographic change on the age at diagnosis in German head and neck cancer (HNC) patients is unclear. Here we present an evaluation of aging trends in HNC at a tertiary referral center. Methods: Retrospective cohort study on aging trends at the initial diagnosis of newly diagnosed patients with HNC between 2004 and 2018 at the head and neck cancer center Ulm in relation to demographic data of the catchment area. Results: The study population consisted of 2450 individuals diagnosed with HNC with a mean age of 62.84 (±11.67) years. We observed a significant increase in annual incidence rates and mean age over time. Mean age among HNC patients increased significantly more than among the population in the catchment area. Whereas the incidence rate of patients <50 years did not change, the incidence of HNC patients aged ≥70 years increased the most. The mean patient age in the main tumor sites increased significantly. Surprisingly, HPV-positive patients were not younger than HPV-negative patients, but showed a non-significant trend towards a higher mean age (63.0 vs. 60.7 years). Conclusions: Increasing incidence rates in older patients pose a challenge for health care systems. A nationwide study is needed to assess the dynamics and impact of aging on the incidence of HNC. [ABSTRACT FROM AUTHOR]

Background: Foehn describes a wind which occurs in areas with close proximity to mountains. The presence of foehn wind is associated with worsening health conditions. This study analyzes the correlation between a foehn typical circulation and the incidence for suffering a severe trauma.Methods: This is a retrospective, multicentre observational register study. The years from 2013 to 2016 were analyzed for the presence of foehn winds. A logistic regression analysis with the number of daily admitted trauma patients as the primary target value was performed in dependence of foehn winds. Southern Bavaria is a typical foehn wind region. Individuals were treated in 37 hospitals of Southern Bavaria which participate in the TraumaRegister DGU®, an international register that includes all severe trauma patients, mainly in Germany. We analyzed patients with an Injury Severity Score (ISS) of at least nine with admission to intensive care units or prior death in the emergency room.Results: 6215 patients were enrolled in this study. A foehn-typical circulation was present on 65 days (4.5%). 301 patients (5%) suffered a trauma with an ISS ≥ 9 on a foehn day. The mean ISS was 20.2 (9-75). On average, 4.3 patients (0-15 patients) were admitted on a daily basis due to a severe trauma. The multivariate regression analysis revealed a daily increase of 0.87 individuals (p = 0.004; 95% CI 0.23-1.47) on foehn days. During spring 1.07 patients (p = < 0.001; 95% CI 0.72-1.42), in summer 1.98 patients (p = < 0.001; 95% CI 1.63-2.32), in fall 0.63 (p = < 0.001; 95% CI 0.28-0.97) and on Saturdays, 0.59 patients (p = < 0.001; 95% CI 0.24-0.93) were additionally admitted due to severe trauma.Conclusion: Foehn winds are significantly associated with severe trauma in trauma centers of the TraumaNetzwerk DGU®. [ABSTRACT FROM AUTHOR]

• The study aims at identifying the relevant factors influencing individual acceptance of alternative fuel vehicles with regard to autonomous driving. • Individual differences, social impacts, and system characteristics were found to determine individual acceptance of an Autonomous Electric Bus (AEB). • For example, the individual factor trust in autonomous driving directly influences the intention to use an AEB, while in comparison the social factor image has a direct influence on perceived usefulness and therefore indirectly influences the attitude towards using and the intention to use an AEB. • The study contributes to the existing body of knowledge by highlighting the importance of accounting for individual perceptions in deriving policy implications and therein for a better diffusion of autonomous driving alternative fuel vehicles. To achieve the widespread diffusion of autonomous electric buses (AEBs) and thus harness their environmental potential, a broad acceptance of new technology-based mobility concepts must be fostered. Still, there remains little known about the factors determining their acceptance, especially in the combination of vehicles with alternative fuels and autonomous driving modes, as is the case with AEBs. In this study, we first conducted qualitative research to identify relevant factors influencing individual acceptance of autonomously driven electric buses. We then developed a comprehensive research model that was validated through a survey of 268 passengers of an AEB, operated in regular road traffic in Germany. The results indicate that a mix of individual factors, social impacts, and system characteristics determine an individual's acceptance of AEBs. Notably, it is important that users perceive AEBs, not only as advantageous, but also trustworthy, enjoyable, and in a positive social light. Our research supplements the existing corpora by demonstrating the importance of individual acceptance and incorporating it to derive policy implications. [ABSTRACT FROM AUTHOR]

• Largest multi-country study on the abundance of antimicrobial resistance genes in veal calves. • We found a significant positive association between trim/sulfa use and faecal sul2 concentrations. • Cleaning practices and the weight of calves at arrival were associated with resistance. High antimicrobial use (AMU) and antimicrobial resistance (AMR) in veal calves remain a source of concern. As part of the EFFORT project, the association between AMU and the abundance of faecal antimicrobial resistance genes (ARGs) in veal calves in three European countries was determined. In 2015, faecal samples of veal calves close to slaughter were collected from farms located in France, Germany and the Netherlands (20 farms in France, 20 farms in the Netherlands and 21 farms in Germany; 25 calves per farm). Standardized questionnaires were used to record AMU and farm characteristics. In total, 405 faecal samples were selected for DNA extraction and quantitative polymerase chain reaction to quantify the abundance (16S normalized concentration) of four ARGs [ aph(3')-III, ermB, sul2 and tetW ] encoding for resistance to frequently used antimicrobials in veal calves. Multiple linear mixed models with random effects for country and farm were used to relate ARGs to AMU and farm characteristics. A significant positive association was found between the use of trimethoprim/sulfonamides and the concentration of sul2 in faeces from veal calves. A higher weight of calves on arrival at the farm was negatively associated with aph(3')-III and ermB. Lower concentrations of aph(3')-III were found at farms with non-commercial animals present. Furthermore, farms using only water for the cleaning of stables had a significantly lower abundance of faecal ermB and tetW compared with other farms. A positive association was found between the use of trimethoprim/sulfonamides and the abundance of sul2 in faeces in veal calves. Additionally, other relevant risk factors associated with ARGs in veal calves were identified, such as weight on arrival at the farm and cleaning practices. [ABSTRACT FROM AUTHOR]