7 results on '"GAO Lei"'
Search Results
2. Association between a pro-inflammatory genetic profile and the risk of chronic atrophic gastritis among older adults from Germany
- Author
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Gao, Lei, Weck, Melanie N., Nieters, Alexandra, and Brenner, Hermann
- Subjects
- *
GASTRITIS , *GENETIC polymorphisms , *STOMACH cancer , *CYTOKINES , *DISEASE susceptibility , *DISEASE risk factors - Abstract
Abstract: Background: Pro-inflammatory polymorphisms have been suggested to explain part of the individual diversity in susceptibility to gastric carcinogenesis. We aimed to assess their impact on the risk of chronic atrophic gastritis (CAG) in a population-based study. Methods: Among 9953 older adults from Saarland/Germany, eight single nucleotide polymorphisms (SNPs) were assessed for 534 cases with serologically defined CAG and 534 age- and sex-matched controls at baseline examination. Results: Of the 8 SNPs, only IL10 T-819C showed a borderline significant association with CAG risk (odds ratio for CC versus TT: 1.67 (95% confidence interval: 1.01โ2.76)). No significant differences were observed for the distribution of inferred haplotypes between cases and controls. However, joint evaluation of several cytokine variants suggested an increased risk of CAG among individuals carrying several pro-inflammatory genotypes. Conclusions: Our findings suggest that a pro-inflammatory genetic profile may contribute to inter-individual variation in gastric cancer risk by increasing the susceptibility to the development of CAG. [Copyright &y& Elsevier]
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- 2009
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3. Grb2-associated binder 1 (Gab1) genetic polymorphism, Helicobacter pylori infection, and chronic atrophic gastritis among older adults from Germany.
- Author
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Gao L, Weck MN, Nieters A, and Brenner H
- Subjects
- Aged, Case-Control Studies, Cohort Studies, Female, Gastritis, Atrophic blood, Genotype, Germany epidemiology, Helicobacter Infections immunology, Helicobacter pylori genetics, Helicobacter pylori immunology, Humans, Male, Middle Aged, Pepsinogen A blood, Pepsinogen A genetics, Adaptor Proteins, Signal Transducing genetics, Gastritis, Atrophic genetics, Helicobacter Infections genetics, Polymorphism, Single Nucleotide
- Abstract
Grb2-associated binder 1 (Gab1) plays an important role in the regulation of cell growth and transformation. A single nucleotide polymorphism (SNP) (rs3805246) in the Gab1 gene has been suggested to be related to the risk of Helicobacter pylori infection and chronic atrophic gastritis (CAG) in a study from Japan. We aimed to assess the associations in a population-based study from Germany. In the baseline examination of ESTHER, a population-based study conducted in Saarland, serum pepsinogen I and II and H. pylori serostatus were measured by ELISA. The Gab1 SNP (rs3805246) was genotyped in 351 serologically defined CAG cases and 351 age- and sex-matched non-CAG controls. A nonsignificant association was observed between the Gab1 SNP and CAG, with an adjusted odds ratio of 1.15 (0.85-1.55) for AA/AG carriers compared to GG carriers. The magnitude of the association did not change when the analysis was restricted to H. pylori seropositive subjects. Furthermore, no significant relation was found between the SNP and H. pylori seropositivity among non-CAG controls. We could not confirm a major association between Gab1 SNP (rs3805246) and the predisposition to H. pylori infection and CAG in this study population from Germany. Further studies with larger sample size are needed to clarify a potential modest effect of Gab1 genetic polymorphisms., (© 2010 Wiley-Liss, Inc.)
- Published
- 2010
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4. Alcohol consumption, serum gamma-glutamyltransferase, and helicobacter pylori infection in a population-based study among 9733 older adults.
- Author
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Gao L, Weck MN, Stegmaier C, Rothenbacher D, and Brenner H
- Subjects
- Aged, Alcohol Drinking blood, Alcoholic Beverages, Cross-Sectional Studies, Enzyme-Linked Immunosorbent Assay, Female, Germany epidemiology, Helicobacter Infections enzymology, Helicobacter Infections microbiology, Humans, Logistic Models, Male, Middle Aged, Sex Factors, Alcohol Drinking epidemiology, Helicobacter Infections epidemiology, Helicobacter pylori isolation & purification, gamma-Glutamyltransferase blood
- Abstract
Purpose: Moderate alcohol consumption has been suggested to facilitate the elimination of Helicobacter pylori infection as the result of its antibacterial effect. We aimed to assess the associations of current and lifetime alcohol consumption as well as serum gamma-glutamyltransferase (GGT), an established biomarker of alcohol consumption, with H. pylori infection in a large population-based study., Methods: In the baseline examination of the ESTHER study, serological measurements of antibodies against H. pylori and GGT measurements were taken in 9733 subjects ages 50 to 74 years. Information on lifestyle factors and medical history were obtained by self-administered standardized questionnaire., Results: A significant inverse association, in dose-response manner, was observed between both current and lifetime alcohol consumption and H. pylori seropositivity. The estimates based on lifetime consumption were more pronounced than the results for current consumption, and such inverse associations were found both for men and women. Stronger relations were observed for those who only drank wine or mixed drinkers compare with those who only drank beer. Furthermore, there was a significant inverse dose-response relationship between serum GGT levels and H. pylori seropositivity, which was selectively observed among alcohol drinkers., Conclusions: In conclusion, our results support the hypothesis that moderate alcohol consumption may facilitate elimination of H. pylori., (2010 Elsevier Inc. All rights reserved.)
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- 2010
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5. Alcohol consumption and chronic atrophic gastritis: population-based study among 9,444 older adults from Germany.
- Author
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Gao L, Weck MN, Stegmaier C, Rothenbacher D, and Brenner H
- Subjects
- Aged, Antibodies, Bacterial blood, Chronic Disease, Enzyme-Linked Immunosorbent Assay, Female, Gastritis, Atrophic blood, Gastritis, Atrophic microbiology, Germany epidemiology, Helicobacter Infections blood, Helicobacter Infections microbiology, Helicobacter pylori immunology, Humans, Male, Middle Aged, Pepsinogen A blood, Pepsinogen C blood, Risk Factors, Alcohol Drinking, Gastritis, Atrophic epidemiology, Helicobacter Infections epidemiology, Helicobacter pylori isolation & purification
- Abstract
Moderate alcohol consumption has been suggested to facilitate elimination of Helicobacter pylori infection which is a key risk factor for chronic atrophic gastritis (CAG) and gastric cancer. The aim of our study was to assess the association of alcohol consumption with CAG among older adults from Germany. In the baseline examination of ESTHER, a population-based study conducted in Saarland, serological measurements of pepsinogen I and II (for CAG definition) and H. pylori antibodies were taken in 9,444 subjects aged 50-74 years. Moderate current (<60 g/week) and lifetime (
- Published
- 2009
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6. Helicobacter pylori infection and gastric cancer risk: evaluation of 15 H. pylori proteins determined by novel multiplex serology.
- Author
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Gao L, Michel A, Weck MN, Arndt V, Pawlita M, and Brenner H
- Subjects
- Aged, Antibodies, Bacterial blood, Antigens, Bacterial immunology, Bacterial Proteins immunology, Chaperonin 60 immunology, Enzyme-Linked Immunosorbent Assay, Female, Germany epidemiology, Helicobacter Infections blood, Helicobacter pylori immunology, Humans, Male, Middle Aged, Stomach Neoplasms blood, Stomach Neoplasms epidemiology, Helicobacter Infections epidemiology, Helicobacter pylori isolation & purification, Stomach Neoplasms microbiology
- Abstract
Infection with Helicobacter pylori is a major cause of gastric cancer (GC). The association likely has been underestimated in the past due to disease-related clearance of the infection. On the other hand, only a minority of the infected individuals develop GC, and better risk stratification is therefore highly desirable. We aimed to assess the association of GC with antibodies to 15 individual H. pylori proteins, determined by novel multiplex serology, to identify potentially relevant risk markers. This analysis was based on 123 GC cases aged 50 to 74 years and 492 age-matched and sex-matched controls from Saarland, Germany. Eight of the antibodies were significantly associated with noncardia GC and seven of them were significantly related to GC at any site. More pronounced associations were observed for noncardia GC; adjusted odds ratios (95% confidence intervals) ranged from 1.60 (1.01-2.54) for HyuA to 5.63 (3.20-9.91) for cytotoxin-associated antigen A (CagA). A dose-response relationship was found between the number of seropositivities and GC (P < 0.001). The seropositivities of CagA and GroEL were found to be independent predictors of GC, which were strongly related to GC risk in a dose-response manner (P < 0.001). In conclusion, GroEL was identified as a new independent risk marker that may contribute to enhanced quantification of H. pylori-related GC risk.
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- 2009
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7. Helicobacter pylori infection and chronic atrophic gastritis: associations according to severity of disease.
- Author
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Weck MN, Gao L, and Brenner H
- Subjects
- Aged, Enzyme-Linked Immunosorbent Assay, Female, Gastritis, Atrophic epidemiology, Gastritis, Atrophic physiopathology, Germany epidemiology, Humans, Male, Middle Aged, Odds Ratio, Surveys and Questionnaires, Gastritis, Atrophic microbiology, Helicobacter Infections epidemiology, Helicobacter pylori isolation & purification, Severity of Illness Index
- Abstract
Background: Helicobacter pylori infection is an established risk factor for chronic atrophic gastritis. However, estimates of the strength of this association have varied widely, possibly due to clearance of the infection in severe stages of chronic atrophic gastritis, which may lead to underestimation of the association. We assessed the association of H. pylori infection with chronic atrophic gastritis according to severity of disease., Methods: We measured serum pepsinogen I and II (as surrogates for chronic atrophic gastritis) and antibodies against H. pylori by ELISA in 9444 men and women aged 50-74 years in a population-based study in Saarland, a state of Germany. The association between H. pylori and chronic atrophic gastritis (defined as pepsinogen I <70 ng/mL and pepsinogen I/II-ratio <3) was analyzed after stratification of chronic atrophic gastritis cases by quintiles of pepsinogen I as proxy marker for severity of chronic atrophic gastritis., Results: When all cases were included, the odds ratio for the association with Chronic atrophic gastritis for H. pylori infection alone was 2.9 (95% confidence interval 2.3-3.6); it was 4.1 (3.2-5.2), for H. pylori infection that was positive for the presence of Ig G antibodies specific to the cytotoxin-associated gene A (CagA) protein-a well-established virulence factor of H. pylori. These ORs ranged from 11 (5.2-22) and 16 (7.7-34) for the quintile of cases with highest pepsinogen I (least severe cases) to 1.0 (0.7-1.6) and 0.9 (0.5-1.5) for the quintile of cases with lowest pepsinogen I (most severe cases). Five of 7 cases with CagA-seropositivity but negative H. pylori serostatus (a pattern indicative of past infection) were in the group of most severe cases., Conclusions: Our results support the hypothesis of major underestimation of the association of H. pylori and chronic atrophic gastritis, due to clearance of the infection in advanced stages of the disease. These results suggest that the association is much stronger than estimated by most epidemiologic studies to date.
- Published
- 2009
- Full Text
- View/download PDF
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