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1. Two-dimensional gel electrophoresis in peritoneal fluid samples identifies differential protein regulation in patients suffering from peritoneal or ovarian endometriosis.

Author

Wölfler MM, Meinhold-Heerlein IM, Söhngen L, Rath W, Knüchel R, Neulen J, Maass N, and Henkel C

Subjects
Adolescent, Adult, Biomarkers analysis, Case-Control Studies, Endometriosis diagnosis, Female, Germany, Humans, Middle Aged, Ovarian Diseases diagnosis, Peritoneal Diseases diagnosis, Tandem Mass Spectrometry, Young Adult, Ascitic Fluid chemistry, Electrophoresis, Gel, Two-Dimensional, Endometriosis metabolism, Ovarian Diseases metabolism, Peritoneal Diseases metabolism, Proteins analysis, Proteomics methods
Abstract

Endometriosis is determined by local and systemic proinflammatory dysregulation and therefore differential protein expression in peritoneal fluid (PF). Of highest interest is lesion formation and the establishment and persistence of endometriosis. In this study we analyzed well-characterized PF samples of patients with ovarian or peritoneal endometriosis and compared them to control samples. We found 11 proteins differentially regulated, of which some might play a key role in the pathogenesis of endometriosis., (Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)

Published
2011
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