1. Dural ectasia in Loeys-Dietz syndrome: comprehensive study of 30 patients with a TGFBR1 or TGFBR2 mutation.
- Author
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Sheikhzadeh, S., Brockstaedt, L., Habermann, C.R., Sondermann, C., Bannas, P., Mir, T.S., Staebler, A., Seidel, H., Keyser, B., Arslan‐Kirchner, M., Kutsche, K., Berger, J., Blankenberg, S., and von Kodolitsch, Y.
- Subjects
LOEYS-Dietz syndrome ,GENETIC mutation ,MARFAN syndrome ,CONNECTIVE tissue cells - Abstract
The purpose of this study was to assess the frequency, severity, and clinical associations of dural ectasia (DE) in Loeys-Dietz syndrome (LDS). Database analysis of three German metropolitan regions identified 30 patients with LDS and TGFBR1 mutation in 6 and a TGFBR2 mutation in 24 individuals (17 men; mean age: 31 ± 19 years), as well as 60 age and sex-matched control patients with Marfan syndrome carrying a FBN1 mutation. DE was present in 22 patients with LDS (73%), and it related to skeletal score points (p = 0.008), non-skeletal score points (p < 0.001), and to the presence of ≥7 systemic score points (p = 0.010). Similarly, the severity of DE was related to body height (p = 0.010) and non-skeletal score points (p = 0.004). Frequency (p = 0.131) and severity of DE (p = 0.567) was similar in LDS and Marfan syndrome. DE is a manifestation of LDS that occurs with similar frequency and severity as in Marfan syndrome. Severity of DE may serve as a marker of the overall connective tissue disease severity. LDS may be considered in patients with DE. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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