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Researchers at Fuzhou University in Fujian, China have made new findings in the field of Chemicals and Chemistry. They have developed a method for the asymmetric [2 + 2 + 2] cycloaddition of unsymmetric BN-diynes with nitriles or unsymmetric alkynes, which allows for the construction of chiral molecules with excellent regioselectivities and high enantioselectivities. The researchers found that the BN-naphthalenyl moiety of diynes is critical for the regioselectivity of this cycloaddition. This research has been peer-reviewed and provides valuable insights into the design and construction of chiral molecules. [Extracted from the article]