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Objective: To examine the current state for ovarian cancer surgery in France from 2009 to 2016 and to examine the impact of the volume of activity on morbidity and mortality by institution., Material and Method: National retrospective study analyzing surgical sessions for ovarian cancer from the program of medicalization of information systems (PMSI), from January 2009 to December 2016. Institutions were divided according to the number of annual curative procedures into 3 groups: A<10; B: 10-19; C≥20. A propensity score (PS) and the Kaplan-Meier method were employed for statistical analyses., Results: In total, 27,105 patients were included. The 1-month mortality rate in group A, B and C was 1.6; 1 and 0.7 %, respectively (P<0.001). Compared to group C, the Relative Risk (RR) of death within the first month was 2.22 for group A and 1.32 for group B (P<0.01). After MS, the 3- and 5-year survival in group A+B and group C were 71.4 and 60.3% (P<0.05) and 56.6, and 60.3% (P<0.05), respectively. The 1-year recurrence rate was significantly lower in group C (P<0.0001)., Conclusion: An annual volume of activity>20 advanced stage ovarian cancers is associated with a decrease in morbidity, mortality, recurrence rate and improved survival., (Copyright © 2023. Published by Elsevier Masson SAS.)

Abstract: Background: Clinical outcomes and socioeconomic consequences after a stroke may differ between regions. Methods: One cohort was established prospectively in Kunming (China) to compare with a cohort of 156 stroke patients included in Limoges (France). During 1 year, patients hospitalized within 48hours for a first-ever hemispheric stroke were included. Demographic data and neurocardiovascular risk factors were registered. Hemiplegia was evaluated. Functional outcome was assessed using the Barthel Index (BI) after 3 months. Results: One hundred and eighteen patients were included in Kunming. Patients of Kunming were younger (61.4±13.4 vs 72.3±14.6 years in Limoges, P <0.0001), more involved in professional activity (36.4% vs 12.8%, P <0.0001). Survival analysis indicated that mortality did not differ between cohorts, but independently predicted by coma at the 2nd day (HR=9.33, 95% CI [4.39, 19.78]) and age>70 years (HR=6.29, 95% CI [2.36, 16.59]). Despite a better baseline BI for patients of Kunming (50.0±34.9 vs 37.4±34.2, P =0.0031), after adjustment for confusing, patients in Limoges had a 2.11 OR 95% CI [1.03, 4.31]) to reach a BI>80 at 3 months. Conclusions: Functional recovery for patients of Kunming was not as good as expected. The socioeconomic consequences of stroke in Kunming are significant as they involved younger subjects who were still in work. [ABSTRACT FROM AUTHOR]

Summary: In 1997 a large French epidemiological study (Epipage) showed increased mortality and morbidity in Languedoc Roussillon when compared to other regions of France. In order to update information, we set up a regional database about very preterm infants born in Languedoc-Roussillon since 2003. Our objective was to analyze the evolution of mortality and of the morbidity in very preterm infants between 1997 and 2003–2005. Methods: We analyzed mortality and the morbidity (respiratory, neurological, digestive) of the very preterm infants born alive between 22 and 32 weeks amenorrhea and admitted alive in neonatology included in Epipage study in 1997 and of those included in the regional database in 2003–2005. Between these 2 periods, professional practices were significantly improved as the perinatal network was set up and perinatal care was regionalized. Results: We analyzed the data collected in 3121 subjects of Epipage study and 1111 subjects of the regional database. We observed a significant reduction (P <0.05) of neonatal mortality (8% versus 23%), rate of bronchopulmonary dysplasia (9% versus 19%) and of periventricular leukomalacia (9% versus 18%). During this period, there were significant increases (P <0.05) in the rates of antenatal corticotherapy (87% versus 61%) and caesarean section (72% versus 38%). Conclusion: We observed a significant improvement of morbidity of very preterm infants and a decreased mortality for the youngest subjects which was concomitant of an improvement of the professional''s practices. It is necessary to take into account these results to propose relevant informations to the professionals with and thus indirectly to the parents. [Copyright &y& Elsevier]

Introduction: Due to an increase in life expectancy, onco-pulmonologists and thoracic surgeons are more frequently faced with octogenarian patients with lung cancer. In this age group, treatment modalities may need to be revised because of the increasing presence of comorbidities. Surgery remains the reference treatment for early stage disease, but mortality rates and postoperative complications are higher in this group of patients. One of the solutions to reduce the operative risk would be to develop videoassisted thoracoscopic pulmonary resection surgery. The aim of this study was to evaluate the results of this form of lung cancer surgery in octogenarians., Methods: All patients 80 years old or more who underwent videoassisted lung cancer surgery from 2014 to 2018 at Lyon University Hospital were included. Wedge resections and diagnostic procedures were excluded., Results: Nineteen patients (13 men, 6 women) were included. The median age was 82 years old. All patients had undergone videoassisted lobectomy. Three patients required conversion to thoracotomy (15.8%). All patients underwent complete resection (R0). One patient had N1 lymph node involvement, all others were N0. The postoperative complication rate was 68.4%, the majority of which were grade II of the Clavien classification. Perioperative mortality was 5.3%., Conclusions: Videoassisted lung cancer resection in a selected population of octogenarians is associated with satisfactory short-term results. It is reasonable to favour minimally invasive techniques in this population, even if the proof of their superiority has not yet been firmly established., (Copyright © 2020 SPLF. Published by Elsevier Masson SAS. All rights reserved.)

Objective: To synthesize current knowledge on definition, frequency, morbidity and risk factors related to term prelabor rupture of membranes., Methods: The MedLine database, the Cochrane Library and French and foreign guidelines from 1980 to 2019 have been consulted., Results: Term rupture of membranes is defined by the rupture of the membranes after 37 weeks of gestation (WG). Term prelabor rupture of membranes is defined by the rupture of membranes prior to the onset of labor after 37 WG. According to unpublished data from the 2016 French National Perinatal Survey, 26,5% of women with singleton pregnancies had a term rupture of membranes before their admission into labor ward. We were not able to assess if those were "prelabor" or not (LE3). Among women admitted with term rupture of membranes, 35,6% were still not in labor 12hours after the rupture i.e. 8,9% of all singleton pregnancies (LE3). Reported rates of term prelabor rupture of membranes vary between 6 and 22% in singleton pregnancies (LE3). Term prelabor rupture of membranes is associated with a risk of fever before (LE3), during (LE3) and after labor (LE3), as well as intrauterine and neonatal infection (LE3). The frequency of these complications in the context of a routine antibiotic prophylaxis is unknown. The expert group chose a delay of 12hours without spontaneous labor to differentiate a physiological situation from a potentially risky situation that could justify a medical intervention (Professional consensus). Risk factors for term prelabor rupture of membranes include history of term prelabor rupture of membranes (LE3), nulliparity (LE3), uterine contractions requiring treatment (LE3) and first trimester bleeding (LE3)., Conclusion: Data on frequency, risk factors and morbidity of term prelabor rupture of membranes are limited or of poor quality., (Copyright © 2019. Published by Elsevier Masson SAS.)

In ovarian, tubal and primary peritoneal cancers, older adults have an over-mortality due to more aggressive disease (NP4), surgical and chemotherapy under treatment (NP4) and co-morbidities (NP4). Older age is at higher risk for postoperative morbidity and mortality (NP4). Surgery is more often incomplete in this elderly population (NP4). Older age is a risk factor for lower dose intensity in adjuvant chemotherapy (NP4) and incomplete chemotherapy (NP4). Nevertheless, the benefit of a complete surgery remains identical to that of the younger population (NP2). Preoperative functional assessment identifies patients at risk for postoperative complications (NP4). The perioperative risk depends on three variables, the ASA score, the age and the complexity score of the surgery (NP4). It is recommended to perform cytoreduction surgery in an expert centre (grade C) and on the basis of geriatric expertise analysing functional and physical performance (grade C). The benefit/risk balance of surgery should be assessed on a case-by-case basis for the most at-risk (NP4) populations defined by: (i) age≥80 years, especially if albuminemia≤37g/L; (ii) age≥75 years and FIGO stage IV; (iii) age≥75 years, stage FIGO III and≥1 comorbidity. A comprehensive geriatric assessment is recommended prior to the management of an elderly person with primary ovarian, tubal or peritoneal cancer (grade C). The GVS (Geriatric Vulnerability Score) is used to identify vulnerable elderly patients (NP2). In fit elderly patients, it is recommended to perform intravenous chemotherapy identical to that of younger patients (ie platinum-based dual therapy) (grade B). In vulnerable elderly patients, various adapted chemotherapy regimens have been prospectively evaluated in non-comparative trials, and seem feasible considering specific and nonspecific toxicities: carboplatin monotherapy (NP2), carboplatin AUC2+paclitaxel 60mg/m 2 3 weeks/4 (NP2), carboplatin AUC 4-5+paclitaxel 135mg/m 2 /3 weeks (NP2), carboplatin AUC5/3 weeks+paclitaxel 60mg/m 2 /week (NP3). In the absence of comparative data, no recommendation can be made in this population. Primary chemotherapy decreases the complexity of the surgical procedure and perioperative morbidity and mortality during interval surgery (NP1). It should be considered after 70 years in cases of comorbidities and/or peritoneal carcinomatosis sufficient for complex initial surgery (NP4)., (Copyright © 2019 Elsevier Masson SAS. All rights reserved.)

Objectives: To synthetize the available evidence regarding the incidence and risk factors of preterm premature rupture of membranes (PPROM). To describe the evolution of pregnancy, neonatal outcomes and the prognosis of infants born in a context of PPROM, according to the existence of an associated intrauterine infection and to the latency duration., Method: Consultation of the Medline database, from 1980 to February 2018., Results: PPROM before 37 and before 34 weeks' gestation occur in 2-3% and <1% of pregnancies, respectively (LE2). Although many risk factors are identified, few are modifiable, and the vast majority of patients have no risk factors (LE2). Consequently, individual prediction of the risk of PPROM and primary prevention measures have not been shown to be effective and are not recommended in clinical practice (Grade B). Most women give birth within the week following PPROM (LE2). The main complications of PPROM are prematurity, intrauterine infection and obstetric and maternal complications (LE2). Latency duration and the frequency of complications decrease with increasing gestational age at PPROM (LE2). Neonatal prognosis is largely conditioned by gestational age at birth, with no apparent over-risk of poor outcomes linked to PPROM compared to other causes of preterm birth (LE2). In contrast, intrauterine infection is associated with an increased risk of in utero fetal death (LE3), necrotizing enterocolitis (LE1) and early-onset sepsis (LE2). The association of intrauterine infection with neurological morbidity remains controversial. Prolongation of latency, from gestational age at PPROM, is beneficial for the child (LE2)., Conclusion: PPROM is a major cause of prematurity and short- and long-term mortality and morbidity. Antenatal care is an important issue for obstetric and pediatric teams, aiming to reduce complications and adverse consequences for both mother and child., (Copyright © 2018 Elsevier Masson SAS. All rights reserved.)

Abstract: This report is devoted to 91 extremely elevated protein C-reactive levels. Patients characteristics, etiologies of inflammation, comorbidities and microbiology are subjected to wide variations. Mortality is high (37 % and 51 %, 30 and 90 days later). [Copyright &y& Elsevier]

A mortality and morbidity (M&M) review consists in analysing, collectively and retrospectively, the cases of patients whose evolution has been marked by a complication or death. This analysis must question whether such an outcome could have been avoided, making it possible to identify the causes and correct the factors having contributed to its occurrence. After a presentation of the methodological and organisational principles, as well as the M&M reviews carried out in France, attention is turned to those performed in psychiatry and identifying the main perspectives for the discipline., (Copyright © 2017 Elsevier Masson SAS. All rights reserved.)

Summary: We compared 88 octogenarians who had a coronary surgery with 165 patients aged between 60 and 70, the two groups having been paired according to the main risk factors. Operative mortality was similar in both groups. Long-term survival was lower for the octogenarians but higher than for the same age French population. [Copyright &y& Elsevier]

Background: The increasing number of obese patients eligible for cardiac surgery requires risks and benefits to be balanced in this population., Aims: To study the results of cardiac surgery in severely obese patients (body mass index [BMI]≥35 kg/m2)., Methods: In this retrospective study of 3564 patients undergoing elective cardiac surgery between 2004 and 2012, the population was divided into two groups: BMI 20-34.9 kg/m2 (n=3282) and BMI≥35 kg/m2 (n=282). Patients with BMI<20 kg/m2 were excluded due to the well-known increased mortality risk. The primary endpoint was 90-day mortality. A multivariable analysis was performed to identify prognostic factors., Results: Among our patients, 58.2% and 27.7% underwent isolated coronary or valvular surgery, respectively; 9.7% had combined valvular and coronary surgery and 4.4% had other procedures. Severely obese patients were younger: 62.5±9.3 years vs 67.8±10.7 years (P=0.0001). Overall 90-day mortality was 4.0%. Severe obesity did not influence postoperative mortality. In the multivariable analysis, the interaction between preoperative renal failure and severe obesity was an important mortality prognostic factor (hazard ratio: 11.17; P=0.03). Mediastinitis rates were similar between groups in non-diabetic patients; in diabetic patients, severe obesity was associated with higher mediastinitis rates (P=0.002). Superficial wound infections were higher in severely obese patients (P=0.003)., Conclusion: Elective cardiac surgery in severely obese patients was not associated with increased perioperative morbimortality, but had a higher superficial wound infection risk. Nevertheless, severe obesity itself should not be a contraindication to elective surgery., (Copyright © 2014 Elsevier Masson SAS. All rights reserved.)