1. Comparative study of the diffusion of five botulinum toxins type-A in five dosages of use: are there differences amongst the commercially-available products?
- Author
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Costa A, Pegas Pereira ES, de Oliveira Pereira M, Calixto dos Santos FB, Favaro R, Stocco PL, and Fávaro de Arruda LH
- Subjects
- Adolescent, Adult, Botulinum Toxins, Type A administration & dosage, China, Double-Blind Method, Drug Industry, Female, France, Humans, Hyperhidrosis drug therapy, In Vitro Techniques, Middle Aged, Neuromuscular Agents administration & dosage, North America, Young Adult, Botulinum Toxins, Type A pharmacokinetics, Neuromuscular Agents pharmacokinetics
- Abstract
Background: Diffusion halo profiles of different commercially available type-A botulinum toxins (BTX-A) have been studied., Objective: To evaluate and compare the largest diameter of diffusion halos of 5 different doses of 5 different commercially available BTX-A., Methods: Twenty-five adult female volunteers were included. Products with 100 units (100 UI) and the product with 500 units (500 UI) were reconstituted in a ratio of 1:2.5. Products were applied in five different concentrations (1 U/2.5 U, 2 U/5 U, 3 U/7.5 U, 4 U/10 U, and 5 U/12.5 U). After 30 days, a starch-iodine test was conducted to obtain the largest diameter of each halo., Results: For all BTX-As, the higher the number of units used, the larger the diameter of the diffusion halo p<0.05). Statistically significant differences (p<0.05) were observed between the North American and Chinese BTX-As for the three lowest doses, between the Korean and German BTX-As for all doses, between the French and Chinese BTX-As for the four highest doses, between the French and German BTX-As for all doses, between the Chinese and German BTX-As for the four highest doses, and between the North American and German BTX-As for all doses (p<0.01)., Conclusions: Differences were observed between all brands of BTX-As and between the different doses of each brand.
- Published
- 2012