1. Assessing change in body composition in children with Duchenne muscular dystrophy: anthropometry and bioelectrical impedance analysis versus dual-energy X-ray absorptiometry.
- Author
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Mok E, Letellier G, Cuisset JM, Denjean A, Gottrand F, and Hankard R
- Subjects
- Adipose Tissue, Body Mass Index, Child, Child, Preschool, Electric Impedance, France, Humans, Male, Randomized Controlled Trials as Topic, Skinfold Thickness, Absorptiometry, Photon methods, Anthropometry methods, Body Composition, Muscular Dystrophy, Duchenne metabolism
- Abstract
Background & Aims: To compare the ability of bioelectrical impedance analysis (BIA) and skinfold thickness (ST) measurements to estimate changes in body composition in Duchenne muscular dystrophy (DMD)., Methods: A secondary analysis was performed on 26 ambulatory DMD boys aged 3-11 y selected for a randomised trial of glutamine supplementation. We assessed fat free mass (FFM) and percentage fat mass (%FM) by BIA (monofrequency (50kHz) unit), ST measurements and a criterion method, dual-energy X-ray absorptiometry (DXA), and repeated these measures 5 mo later at 3 outpatient clinical investigation centers in France., Results: When compared with DXA reference method, ST overestimated change in FFM (P<0.01), whereas BIA estimates did not differ from DXA. Concordance plots revealed that when compared with DXA, ST overestimated the increase in FFM (mean: 0.6 kg; 95% CI: 0.17 to 0.99) which led to an underestimation in %FM change (mean: -1.4%; 95% CI: -2.6 to -0.2), whereas BIA estimated change in FFM (mean: -0.05 kg; 95% CI: -0.39 to 0.29) and %FM (mean: 1.3%; 95% CI: -0.06 to 2.7) more accurately., Conclusions: BIA method can be used to follow changes in nutritional status of ambulatory DMD children or to evaluate treatment efficacy., (Copyright © 2010 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.)
- Published
- 2010
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