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To identify prognostic factors of invasive–disease free survival (iDFS) in women with non-metastatic hormone receptor positive (HR+) breast cancer (BC) in daily routine practice. We performed a retrospective study using data from the Côte d'Or breast and gynecological cancer registry in France. All women diagnosed with primary invasive non-metastatic HR + BC from 1998 to 2015 and treated by endocrine therapy (ET) were included. Women with bilateral tumors or who received ET for either metastasis or relapse were excluded. We performed adjusted survival analysis and Cox regression to identify prognostic factors of iDFS. A total of 3976 women were included. Age at diagnosis, ET class, SBR grade, treatment, stage and comorbidity were independently associated with iDFS. Women who had neither surgery nor radiotherapy had the highest risk of recurrence (HR = 3.75, 95%CI [2.65–5.32], p < 0.0001). Receiving aromatase inhibitors (AI) was associated with a lower risk of recurrence (HR = 0.70, 95%CI [0.54–0.90], p = 0.055) compared to tamoxifen. Compared to women with no comorbidities, women with 1 or 2 comorbidities were more likely to receive AI (OR = 1.63, 95%CI [1.22–2.17], p = 0.0009). Comorbidities, age at diagnosis and previous treatment were associated with iDFS in non-metastatic HR + BC patients. This study also showed that women who received tamoxifen for their cancer experienced worse iDFS compared to women treated with AI. • Treatment with AI was associated with a lower risk of recurrence. • Comorbidities are strong predictor of iDFS in breast cancer. • Radiotherapy after BCS was associated with a lower recurrence risk. • Age, comorbidity and histological type predict the choice of endocrine therapy. [ABSTRACT FROM AUTHOR]

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The article presents research which looks at foster parents who raise immigrant Bamiléké children from Cameroon in France. It describes and analyzes how the practice of transnational fosterage observed between the Bamiléké living in Cameroon and their counterparts who immigrated to France changed. The characteristics of fosterage as it is practiced in Cameroon are presented. The foster parents having to deal with two different educational contexts is also discussed.

Abstract: Using cross-national comparative analysis, this paper discusses the reasons why France has succeeded in partially privatizing its most recently constructed high speed line, while the U.S. has not reached this stage. The authors argue that France, with an interventionist government, diverged from the U.S. during the Great Depression by nationalizing its private railways and regulating competition with highway-based transport, thereby establishing favorable conditions for the future development of high speed trains. The U.S., because of its strong free market orientation, delayed nationalization until 1971, by which time passenger railways were severely weakened, so the U.S. lagged far behind France. After accruing a large public debt on its high speed rail program in the 1980s and 1990s, the French government recently took steps to privatize construction and operations on its Tours–Bordeaux line. Similarly, in the U.S., the State of California is trying to attract private participation on its planned high speed line between San Francisco and Los Angeles. Based on French high speed rail history, this paper argues that, to succeed, California must commit both a high level of public borrowing as well as public guarantees on private borrowing. Public credit is the sine qua non of financing high speed trains. [Copyright &y& Elsevier]

Copyright of Bulletin des bibliothèques de France is the property of ENSSIB and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In recent decades, the living conditions of young breast cancer (BC) survivors have garnered increasing attention. This population-based study aimed to identify the clinical, social and economic determinants of Health-Related Quality of Life (HRQoL), and to describe other living conditions of young long-term BC survivors. Women with non-metastatic BC diagnosed between 2006 and 2015, aged 45 years and younger at the time of diagnosis, were identified through the Breast and Gynecologic Cancer Registry of the Côte d'Or, France. Participants completed self-report questionnaires including standardized measures of HRQoL, anxiety, depression, social deprivation, social support and sexuality. Fertility and professional reintegration issues were also assessed. The determinants of HRQoL were identified using mixed regression model. In total, 218 BC survivors participated in the survey. The main determinants of poor HRQoL were anxiety, depression, comorbidities, social deprivation and menopausal status. Among 72% of women who did not receive information about fertility preservation, 38% of them would have liked to have been informed. Finally, 39% of survivors reported a negative impact of BC on their professional activity. This study showed that BC stage or treatments did not have an impact on HRQOL of young long-term BC survivors. Fertility, sexuality and professional reintegration remained the main concerns for survivors. Specific interventions in these population should focus on these issues. [ABSTRACT FROM AUTHOR]