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Cross-sensitization between two plant allergens, Frullania and Laurus Nobilis (L), has been demonstrated in Strasbourg. A review of the haptens isolated from Frullania outlines the importance of the purification of allergen to ascertain the nature of the Causative agent. New results on laurel oil point to the possibility of a common denominator (the α-methylene γ-butyrolactone moiety) between this plant and Frullania; former results are re-interpreted and analyzed. In conclusion, the importance of physico-chemical methods used to purify and isolate haptens, and help in their definition, is stressed. [ABSTRACT FROM AUTHOR]

22 cases of allergic contact dermatitis from topical corticosteroids were observed in Strasbourg and previously published 7 further cases are reported here and the vehicle and concentration of corticosteroids for patch tests are discussed. A 0.1% concentration in petrolatum seemed adequate for testing the 4 molecules (triamcinolone acetonide, dexamethasone, desonide and amcinonide) responsible for the 7 new, cases. In 1 case, several cross-reactions were seen. A corticosteroids screening series permits patch testing of the suspected molecule(s) in a selective way. Without this series, long delays arc required to make [he correct diagnosis by patch testing. We have reviewed more than 60 paper on corticosteroids allergy published up to now. [ABSTRACT FROM AUTHOR]