9 results on '"Demar, Magalie"'
Search Results
2. Leishmaniasis epidemiology in endemic areas of metropolitan France and its overseas territories from 1998 to 2020.
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Pasquier, Grégoire, Demar, Magalie, Lami, Patrick, Zribi, Asma, Marty, Pierre, Buffet, Pierre, Desbois-Nogard, Nicole, Gangneux, Jean Pierre, Simon, Stéphane, Blaizot, Romain, Couppié, Pierre, Thiebaut, Louis, Pratlong, Francine, Dedet, Jean-Pierre, Bastien, Patrick, Sterkers, Yvon, Ravel, Christophe, and Lachaud, Laurence
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LEISHMANIASIS , *NON-self-governing territories , *CUTANEOUS leishmaniasis , *METROPOLITAN areas , *PROTOZOAN diseases , *TRICHOMONIASIS - Abstract
Background: In France, leishmaniasis is endemic in the Mediterranean region, in French Guiana and to a lesser extent, in the French West Indies. This study wanted to provide an updated picture of leishmaniasis epidemiology in metropolitan France and in its overseas territories. Methodology/Principal findings: Leishmaniasis cases were collected by passive notification to the French National Reference Centre for Leishmaniases (NRCL) in Montpellier from 1998 to 2020 and at the associated Centre in Cayenne (French Guiana) from 2003 to 2020. In metropolitan France, 517 autochthonous leishmaniasis cases, mostly visceral forms due to Leishmania infantum (79%), and 1725 imported cases (French Guiana excluded), mainly cutaneous leishmaniasis from Maghreb, were recorded. A slight decrease of autochthonous cases was observed during the survey period, from 0.48 cases/100,000 inhabitants per year in 1999 (highest value) to 0.1 cases/100,000 inhabitants per year in 2017 (lowest value). Conversely, imported cases increased over time (from 59.7 in the 2000s to 94.5 in the 2010s). In French Guiana, 4126 cutaneous and mucocutaneous leishmaniasis cases were reported from 2003 to 2020. The mean incidence was 103.3 cases per 100,000 inhabitants/year but varied in function of the year (from 198 in 2004 to 54 in 2006). In Guadeloupe and Martinique (French West Indies), only sporadic cases were reported. Conclusions/Significance: Because of concerns about disease expansion and outbreaks in other Southern Europe countries, and leishmaniasis monitoring by the NRCL should be continued and associated with a more active surveillance. Author summary: Leishmaniasis is a disease due to a protozoan parasite and transmitted by sandfly. In France, this disease is endemic in the Mediterranean region, in French Guiana and to a lesser extent, in the French West Indies. We wanted to provide an updated picture of leishmaniasis epidemiology in metropolitan France and in its overseas territories. In metropolitan France, from 1998 to 2020, 517 autochthonous leishmaniasis cases, mostly visceral forms due to Leishmania infantum (79%), and 1725 imported cases (French Guiana excluded), mainly cutaneous leishmaniasis from Maghreb, were recorded. A slight decrease of autochthonous cases was observed during the survey period, from 0.48 cases/100,000 inhabitants per year in 1999 to 0.1 cases/100,000 inhabitants per year in 2017. Conversely, imported cases increased over time (from 59.7 in the 2000s to 94.5 in the 2010s). In French Guiana, 4126 cutaneous and mucocutaneous leishmaniasis cases were reported from 2003 to 2020. The mean incidence was 103.3 cases per 100,000 inhabitants/year but varied in function of the year (from 198 in 2004 to 54 in 2006). In Guadeloupe and Martinique (French West Indies), only sporadic cases were reported. Because of concerns about disease expansion and outbreaks, leishmaniasis monitoring should be continued and associated with a more active surveillance. [ABSTRACT FROM AUTHOR]
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- 2022
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3. Precariousness, Diabetes Control and Complications in French Guiana.
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Linière, Samuel, Nacher, Mathieu, Alsibai, Kinan Drak, Mergeayfabre, Mayka, Hafsi, Nezha, Charpin, Aurelie, Misslin-Tritsch, Caroline, Carod, Jean-François, Aurelus, Jean Markens, De Toffol, Bertrand, Ntoutoum, André, Kakamba, John Bukasa, Demar, Magalie, Helene-Pelage, Jeannie, Adenis, Antoine, and Sabbah, Nadia
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DIABETES complications ,FRENCH language ,GLYCEMIC control ,UNIVERSAL healthcare ,DIABETES - Abstract
Aims: The social parameters of an individual impact the incidence of cardiovascular diseases. French Guiana, an overseas French territory with a lower standard of living than France, has a prevalence of diabetes mellitus that is twice that of mainland France. In this context we aimed to study the relation between precariousness, diabetes complications and glycemic control. Methods: A multicenter prospective cohort was initiated since May 2019. 1243 patients were included and their outcomes and history were compared between the precarious and non-precarious based on their EPICES score, a score that measures social isolation and precariousness. Results: 73.3% of the sample was considered precarious. Retinopathy was significantly more frequent among the deprived. There were no significant differences for other macro or microvascular complications. There was a significant difference in Glycated Haemoglobin between the precarious and non-precarious groups (8.3% (67 mmol/l) vs 8.8% (73mmol/l)). After adjusting for potential confounders, precariousness was no longer associated with poor glycemic control; the independent factors significantly associated with poor glycemic control were: not being fluent in French, having creole or portugese as mother language, and not having any insurance. Conclusions: Precariousness is a risk factor for retinal complications in patients with diabetes mellitus in French Guiana. In this chronic disease, the universal healthcare system alleviates health inequalities for many, but not all, diabetic complications. Translation and cultural mediation may further reduce health inequalities in this multicultural territory where a substantial proportion of the population is not fluent in French. [ABSTRACT FROM AUTHOR]
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- 2022
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4. Clinical and histological characteristics, and management of melanoma in French Guiana, 2007–2018.
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Broly, Marine, Drak Alsibai, Kinan, Cenciu, Beatrice, Guevara, Hemerson, Fayette, Jerome, Neidhardt, Eve‐Marie, Demar, Magalie, Couppie, Pierre, and Blaizot, Romain
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MELANOMA ,PUBLIC health ,GENDER - Abstract
There are few studies available on melanoma in Afro‐Caribbean and Amerindian populations of South America. French Guiana deserves a study due to its specific health system and diversity of phototypes. The objectives of this study were to evaluate the incidence, histological and clinical characteristics of melanoma in French Guiana. A retrospective study was conducted from October 2007 to January 2018 on all primary melanomas observed at the Cayenne Hospital Centre. Thirty‐nine patients were included. The incidence rate (1.61/106 inhabitants/year) was low compared with mainland France. Median age was 58, and gender ratio 1 : 16. Clear phototype (I/II) patients were the most frequent (38.5%), but a significant amount of melanoma also occurred in darker skin. Median Breslow was higher in dark phototypes than in fair‐skinned patients. Superficial spreading melanoma (SSM) was the most common histological type (33.3%), particularly in patients with clear phototype (61.5%). Acral lentiginous melanoma was found only in darker‐skinned patients (29.1%). The trunk was involved in 66.6% in the clearest group whereas foot was the most common location in the darkest group (60% in V/VI phototypes). Surgery was the most frequently used treatment (79.5%). At the end of the study period, 53.8% had been lost to follow‐up. In conclusion, the incidence of melanoma in French Guiana is lower than in mainland France but remains a public health concern, as dark‐skinned populations often present with advanced diseases. Awareness and prevention in these communities must be improved. [ABSTRACT FROM AUTHOR]
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- 2020
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5. Acute Lung, Heart, Liver, and Pancreatic Involvements with Hyponatremia and Retinochoroiditis in a 33-Year-Old French Guianan Patient.
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Groh, Matthieu, Faussart, Alexandra, Villena, Isabelle, Ajzenberg, Daniel, Carme, Bernard, Demar, Magalie, Joly, Véronique, Houze, Sandrine, Simon, Stéphane, Aubert, Dominique, Charlois-Ou, Cécile, and Yeni, Patrick
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FRENCH Guianese ,HYPONATREMIA ,PANCREATITIS ,MACROLIDE antibiotics ,HOSPITALS ,TOXOPLASMA gondii ,DIAGNOSIS - Abstract
The article presents a case study of a 33-year-old French Guianan admitted in the Bichat hospital in Paris, France with a 3-week history of fever associated with confusion and dyspnea. Blood examination reveals hyponatremia, pancreatitis, mild hepatitis, and elevated cardic markers. The patient administered macrolide therapy and gold standard anti-toxoplasmosis treatment was also started after the serological diagnosis of Toxoplasma gondii (T. gondii) infection.
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- 2012
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6. Features of cryptococcosis among 652 HIV-seronegative individuals in France: a cross-sectional observational study (2005-2020).
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Paccoud, Olivier, Desnos-Ollivier, Marie, Persat, Florence, Demar, Magalie, Boukris-Sitbon, Karine, Bellanger, Anne-Pauline, Bonhomme, Julie, Bonnal, Christine, Botterel, Françoise, Bougnoux, Marie-Elisabeth, Brun, Sophie, Cassaing, Sophie, Cateau, Estelle, Chouaki, Taieb, Cornet, Muriel, Dannaoui, Eric, Desbois-Nogard, Nicole, Durieux, Marie-Fleur, Favennec, Loïc, and Fekkar, Arnaud
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CRYPTOCOCCOSIS , *SYMPTOMS , *CROSS-sectional method , *SCIENTIFIC observation , *LUNG infections - Abstract
We aimed to describe features and outcomes of cryptococcosis among HIV-seronegative individuals in a large surveillance network for cryptococcosis in France. We included incident cases of cryptococcosis in HIV-seronegative individuals from 2005 to 2020. We compared patient characteristics, disease presentations, cryptococcal antigen results, and induction antifungal treatments according to underlying disease. We examined factors associated with 90-day mortality. Among patients with disseminated infections, we investigated whether receipt of flucytosine and polyene combination was associated with lower mortality. Among 652 individuals, 209 (32.1%) had malignancy, 130 (19.9%) were solid-organ transplant recipients, 204 (31.3%) had other immunocompromising conditions, and 109 (16.7%) had no reported underlying factor. The commonest presentations were disseminated infections (63.3%, 413/652) and isolated pulmonary infections (25.3%, 165/652). Solid-organ transplant patients were most likely to have disseminated infections and a positive serum cryptococcal antigen result. Patients with malignancy were older and less likely to receive a flucytosine-containing regimen for disseminated infections than others (58.7%, 78/133 vs. 73.2%, 194/265; p 0.029). The crude 90-day case-fatality ratio was 27.2% (95% CI, 23.5%–31.1%). Age ≥60 years (aOR: 2.75 [1.78–4.26]; p < 0.001), meningitis/fungaemia (aOR: 4.79 [1.80–12.7]; p 0.002), and malignancy (aOR: 2.4 [1.14–5.07]; p 0.02) were associated with higher 90-day mortality. Receipt of flucytosine and polyene combination was associated with lower 90-day mortality (aOR: 0.40 [0.23–0.71]; p 0.002) in multivariable analysis and inverse probability of treatment weighted analysis (aOR: 0.45 [0.25–0.80]; p 0.006). HIV-seronegative individuals with cryptococcosis comprise a wide range of underlying conditions with different presentations and outcomes, requiring a tailored approach to diagnosis and management. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Evolution of the prevalence of intestinal parasitic infections among the French armed forces in French Guiana.
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Christen, Jacques-Robert, Mura, Marie, Roudaut, Gwenaëlle, Drogoul, Anne-Sophie, Demar, Magalie, Briolant, Sébastien, Garnotel, Eric, Simon, Fabrice, and Pommier De Santi, Vincent
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EOSINOPHILIA ,GOLD ,HELMINTHIASIS ,INTESTINAL parasites ,MINERAL industries ,MILITARY personnel ,DISEASE prevalence ,CROSS-sectional method ,DIAGNOSIS - Abstract
Two cross-sectional studies were performed 2 years apart in French military personnel deployed from France to French Guiana. In 2011, military medical centres in French Guiana reported 40 cases of intestinal parasitism in service members returning from illegal gold mining sites in the rainforest. In 2013, 48 out of 132 service members returning from French Guiana after a 4-month mission had eosinophilia and seven were infected with hookworm. A presumptive first-line treatment with albendazole could be the most pragmatic strategy. [ABSTRACT FROM AUTHOR]
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- 2016
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8. Comparison between emerging Q fever in French Guiana and endemic Q fever in Marseille, France.
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Edouard S, Mahamat A, Demar M, Abboud P, Djossou F, and Raoult D
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- Acute Disease, Adolescent, Adult, Aged, Aged, 80 and over, Cardiovascular Diseases microbiology, Coxiella burnetii, DNA, Bacterial isolation & purification, Female, France epidemiology, French Guiana epidemiology, Humans, Immunoglobulin G blood, Incidence, Male, Middle Aged, Prevalence, Q Fever immunology, Q Fever transmission, Retrospective Studies, Risk Factors, Young Adult, Communicable Diseases, Emerging, Endemic Diseases, Q Fever diagnosis, Q Fever epidemiology
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Q fever is an emergent disease in French Guiana. We compared the incidence clinical and serologic profiles between patients from Cayenne, French Guiana and Marseille in metropolitan France during a four-year period. The annual incidence of diagnosed acute Q fever was significantly higher in Cayenne (17.5/100,000) than in Marseille (1.9/100,000) (P = 0.0004), but not the annual incidence of endocarditis (1.29 versus 0.34/100,000). Most patients had fever (97%) and pneumonia (83%) in Cayenne versus 81% and 8% in Marseille (P < 0.0001 and P < 0.0001, respectively) but transaminitis was more common in patients from Marseille (54% versus 32%; P < 0.0001). The proportion of patients with cardiovascular infections was significantly lower in Cayenne (7%) than in Marseille (17%) (P = 0.017), although they showed a stronger immune response with higher levels of phase I IgG (P = 0.024). The differing epidemiology, clinical, and serologic responses of patients from Cayenne and Marseille suggest a different source of infection and a different strain of Coxiella burnetii.
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- 2014
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9. Suppurative epididymo-orchitis and chronic prostatitis caused by Burkholderia pseudomallei: a case report and review.
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Demar M, Ferroni A, Dupont B, Eliaszewicz M, and Bourée P
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- Chronic Disease, France, Humans, Male, Melioidosis diagnosis, Melioidosis drug therapy, Middle Aged, Myanmar, Suppuration, Travel, Epididymitis microbiology, Melioidosis complications, Orchitis microbiology, Prostatitis microbiology
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- 2005
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