Search

Your search keyword '"Blood Chemical Analysis economics"' showing total 3 results
Start Over Descriptor "Blood Chemical Analysis economics" Region france
3 results on '"Blood Chemical Analysis economics"'

1. [Assessment for antihypertensive drug intake: How, where and when?]

Author

Bouhanick B, Fonquernie P, Bedue I, Schavgoulidze A, and Gandia P

Subjects
Antihypertensive Agents analysis, Antihypertensive Agents economics, Biological Availability, Blood Chemical Analysis economics, Blood Chemical Analysis methods, Clinical Laboratory Services economics, Clinical Laboratory Techniques economics, Costs and Cost Analysis, Dose-Response Relationship, Drug, Drug Monitoring economics, France epidemiology, Humans, Hypertension epidemiology, Hypertension metabolism, Medication Adherence, Patient Care Planning, Urinalysis economics, Urinalysis methods, Antihypertensive Agents pharmacokinetics, Antihypertensive Agents therapeutic use, Clinical Laboratory Techniques methods, Drug Monitoring methods, Hypertension drug therapy
Abstract

Aim: Hypertension is a public health problem managed according to therapeutic strategies published in France by the Hauteautoritéde santé (HAS - French Health Authorities). For patients with resistant hypertension, related or not to a non-adherence, prescribers need to be sure the exposure is high enough to achieve the tensional target. Quantitative analysis of antihypertensive drugs in different biological matrices (blood/urine) is one possible solution. However, this involves determining the concentrations observed at standard doses and knowing how to interpret the measured concentrations. It is also necessary to identify medical laboratories that can assay antihypertensive drugs. This was the aim of our work., Methods: The main antihypertensive drugs recommended by the HAS have been listed. For each of them, we looked for published steady-state plasma/serum concentrations and quantities excreted in the urine at usual dosages. In addition, the elimination half-life and linear pharmacokinetic profile were specified for each antihypertensive agent measured in plasma/serum. Pharmacology-Toxicology laboratories in France likely to carry out assays were identified. The time taken to report the result and the cost of the analysis were also specified., Results: All of the afore-mentioned information has been collected and presented in a table. This can then be used to compare the plasma/serum concentration or the quantity measured in a patient's urine with the values reported in the literature. In cases where the blood sampling times differ between those of the patient and the published data, the patient's measured value is compared to the estimated value based on the published concentrations and pharmacokinetics., Conclusion: Interpretation of the plasma/serum/urinary value measured or estimated for an antihypertensive drug is a particularly interesting approach to determine if drug exposure is enough and a possible non-adherence. However, this activity is mostly carried out in hospital centres., (Copyright © 2019. Published by Elsevier Masson SAS.)

Published
2019
Full Text
View/download PDF

2. [Measurements of PSA and of vitamin D: a period of 3-months of use of special forms based on the guidelines of the Haute autorité de santé shows a clear improvement of prescription behaviors].

Author

Watine J

Subjects
Blood Chemical Analysis economics, Blood Chemical Analysis standards, Blood Chemical Analysis statistics & numerical data, Ethics, Medical, France epidemiology, Humans, Kallikreins blood, Practice Patterns, Physicians' ethics, Practice Patterns, Physicians' standards, Practice Patterns, Physicians' statistics & numerical data, Prescriptions statistics & numerical data, Prostate-Specific Antigen blood, Quality of Health Care, Vitamin D blood, Guideline Adherence trends, Kallikreins analysis, Practice Patterns, Physicians' trends, Prescriptions standards, Prostate-Specific Antigen analysis, Records standards, Vitamin D analysis
Abstract

In France practice guidelines of the Haute Autorité de santé (HAS) are not implemented as often as they should. As a consequence resources are wasted that could be useful elsewhere. In Avril 2014 prescription-forms were introduced in our hospital for PSA and for vitamin-D. If those forms were not filled-in by the physicians, then PSA and vitamin-D were not measured any more by our laboratory. PSA was measured in only two circumstances: therapeutic follow-up of, or screening for, prostate cancer. Patients had to give their formal consent for being screened with PSA. Vitamin-D was measured in the only six circumstances recommended by the HAS. After a few months of use of these two forms we observe a sharp decrease in PSA, and even more so in vitamin D, measurements. Our prescription-forms' legitimacy is high because they are based on governmental guidelines. All the more since the values that are promoted in these guidelines clearly cover the four core principles of bioethics, that is beneficence, non-malevolence, respect for the patient's autonomy (particularly for PSA) and equity. Our results need to be confirmed over a longer period of time, and to be analysed in more detail, particularly regarding the way consent forms are filled-in by the patients.

Published
2015
Full Text
View/download PDF

3. On the choice of an organization for a pathology laboratory.

Author

Auray JP, Collombel C, Duru G, and Richard-Couturier L

Subjects
Blood Chemical Analysis economics, Cost-Benefit Analysis, Diagnostic Tests, Routine economics, Diagnostic Tests, Routine instrumentation, France, Humans, Mathematics, Models, Theoretical, Hospital Departments organization & administration, Laboratories organization & administration, Pathology Department, Hospital organization & administration
Abstract

The study describes an approach to the optimal allocation of sample analysis in a pathology laboratory. The paper consists of three parts: identification of the problem to be resolved; description of the model and application of the model to the organization of a specific laboratory.

Published
1985
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results