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The article reports on the Third International Conference on Pediatric Continuous Renal Replacement Therapy (PCRRT), which took place in Orlando, Florida, from 24th to 26th June 2004. Attendees from 13 countries made up an audience that totaled 230 nursing staff, physicians, pharmacists and representatives from industry. The ongoing success of this meeting is due to the energy and interest of clinicians at bedside who wish to improve the outcome in children with acute renal failure and multi organ system failure. The next conference on PCRRT will occur in Zurich, Switzerland.