1. Cluster of iniencephaly in Miami.
- Author
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Rodriguez MM, Reik RA, Carreno TD, and Fojaco RM
- Subjects
- Abnormalities, Multiple pathology, Anencephaly pathology, Cluster Analysis, Female, Florida epidemiology, Hispanic or Latino, Humans, Infant, Newborn, Male, Neural Tube Defects pathology, Abnormalities, Multiple ethnology, Anencephaly ethnology, Neural Tube Defects ethnology
- Abstract
This report details a cluster of 5 cases of iniencephaly with anencephaly and rachischisis occurring over a 4-month period at Jackson Memorial Hospital/University of Miami Medical Center in Miami, Florida. All 5 cases of this rare, lethal, congenital malformation seen in the cluster included diaphragmatic defects with accompanying hernia, omphalocele, small adrenals, renal dysmaturity, gastrointestinal malformations, cleft lip and palate, and hypoplastic lungs. No single causative agent for this cluster was identified. A brief review of the literature regarding categorization of these malformations and as a discussion of the embryological basis for these lesions and possible etiologic factors are included.
- Published
- 1991
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