1. Virus Antibody Survey in Different European Populations Indicates Risk Association Between Coxsackievirus B1 and Type 1 Diabetes.
- Author
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Oikarinen, Sami, Tauriainen, Sisko, Hober, Didier, Lucas, Bernadette, Vazeou, Andriani, Sioofy-Khojine, Amirbabak, Bozas, Evangelos, Muir, Peter, Honkanen, Hanna, Ilonen, Jorma, Knip, Mikael, Keskinen, Päivi, Saha, Marja-Terttu, Huhtala, Heini, Stanway, Glyn, Bartsocas, Christos, Ludvigsson, Johnny, Taylor, Keith, and Hyöty, Heikki
- Subjects
COXSACKIEVIRUSES ,DIABETES ,ENTEROVIRUSES ,DIABETES in children ,CHILDREN - Abstract
Enteroviruses (EVs) have been connected to type 1 diabetes in various studies. The current study evaluates the association between specific EV subtypes and type 1 diabetes by measuring typespecific antibodies against the group B coxsackieviruses (CVBs), which have been linked to diabetes in previous surveys. Altogether, 249 children with newly diagnosed type 1 diabetes and 249 control children matched according to sampling time, sex, age, and country were recruited in Finland, Sweden, England, France, and Greece between 2001 and 2005 (mean age 9 years; 55% male). Antibodies against CVB1 were more frequent among diabetic children than among control children (odds ratio 1.7 [95% Cl 1.0-2.9]), whereas other CVB types did not differ between the groups. CVB1-associated risk was not related to HLA genotype, age, or sex. Finnish children had a lower frequency of CVB antibodies than children in other countries. The results support previous studies that suggested an association between CVBs and type 1 diabetes, highlighting the possible role of CVB1 as a diabetogenic virus type. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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