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Your search keyword '"Celius, Elisabeth G."' showing total 2 results
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2 results on '"Celius, Elisabeth G."'

1. Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis.

Author

Lundmark F, Duvefelt K, Iacobaeus E, Kockum I, Wallström E, Khademi M, Oturai A, Ryder LP, Saarela J, Harbo HF, Celius EG, Salter H, Olsson T, and Hillert J

Subjects
Adult, Case-Control Studies, Denmark, Female, Finland, Gene Expression, Gene Frequency, Genetic Variation, Genotype, Humans, Interleukin-7 genetics, Leukocytes, Mononuclear cytology, Leukocytes, Mononuclear metabolism, Linkage Disequilibrium, Logistic Models, Male, Middle Aged, Multiple Sclerosis cerebrospinal fluid, Norway, RNA, Messenger genetics, RNA, Messenger metabolism, Reverse Transcriptase Polymerase Chain Reaction, Risk Factors, Sweden, Genetic Predisposition to Disease, Multiple Sclerosis genetics, Polymorphism, Single Nucleotide, Receptors, Interleukin-7 genetics
Abstract

Multiple sclerosis is a chronic, often disabling, disease of the central nervous system affecting more than 1 in 1,000 people in most western countries. The inflammatory lesions typical of multiple sclerosis show autoimmune features and depend partly on genetic factors. Of these genetic factors, only the HLA gene complex has been repeatedly confirmed to be associated with multiple sclerosis, despite considerable efforts. Polymorphisms in a number of non-HLA genes have been reported to be associated with multiple sclerosis, but so far confirmation has been difficult. Here, we report compelling evidence that polymorphisms in IL7R, which encodes the interleukin 7 receptor alpha chain (IL7Ralpha), indeed contribute to the non-HLA genetic risk in multiple sclerosis, demonstrating a role for this pathway in the pathophysiology of this disease. In addition, we report altered expression of the genes encoding IL7Ralpha and its ligand, IL7, in the cerebrospinal fluid compartment of individuals with multiple sclerosis.

Published
2007
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2. Association analysis of the LAG3 and CD4 genes in multiple sclerosis in two independent populations.

Author

Lundmark F, Harbo HF, Celius EG, Saarela J, Datta P, Oturai A, Lindgren CM, Masterman T, Salter H, and Hillert J

Subjects
Adult, Antigens, CD immunology, Biomarkers metabolism, CD4 Antigens immunology, Case-Control Studies, Cohort Studies, DNA Mutational Analysis, Denmark epidemiology, Female, Finland epidemiology, Gene Frequency genetics, Genetic Markers genetics, Genetic Markers immunology, Genetic Testing, Humans, Linkage Disequilibrium, Male, Middle Aged, Multiple Sclerosis epidemiology, Multiple Sclerosis immunology, Norway epidemiology, Predictive Value of Tests, Sweden epidemiology, White People genetics, Lymphocyte Activation Gene 3 Protein, Antigens, CD genetics, CD4 Antigens genetics, Genetic Predisposition to Disease genetics, Multiple Sclerosis genetics, Polymorphism, Single Nucleotide genetics
Abstract

We have investigated the genetic involvement of the CD4 and the LAG3 genes, two appealing candidates for MS due to their suggested role in MS pathology. We genotyped a Swedish case-control material consisting of 920 MS patients and 778 controls in an initial study of CD4, three SNPs showed a significant association with MS. An independent material consisting of 1720 Nordic MS patients and 1416 controls were used for confirmation of associated markers in CD4 and to do a confirmative study of the LAG3 gene from previous findings. The result, including a total of 2640 MS patients and 2194 controls shows no significant association with CD4 and LAG3 and MS. We conclude that these genes are of minor importance in regard of genetic predisposition to the MS.

Published
2006
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