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Start Over Author "Licciardi, P.V." Region fiji
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1. Safety and immunogenicity of the 23-valent pneumococcal polysaccharide vaccine at 12 months of age, following one, two, or three doses of the 7-valent pneumococcal conjugate vaccine in infancy

Author

Russell, F.M., Licciardi, P.V., Balloch, A., Biaukula, V., Tikoduadua, L., Carapetis, J.R., Nelson, J., Jenney, A.W.J., Waqatakirewa, L., Colquhoun, S., Cheung, Y.B., Tang, M.L.K., and Mulholland, E.K.

Subjects
*PNEUMOCOCCAL vaccines, *MEDICATION safety, *POLYSACCHARIDES, *IMMUNOGENETICS, *DRUG dosage, *PHARMACODYNAMICS, *SEROTYPES, *VACCINATION of infants, *THERAPEUTICS
Abstract

Abstract: Fijian infants aged 6 weeks were stratified by ethnicity and randomized to receive 0, 1, 2, or 3 PCV-7 doses with or without the 23-valent pneumococcal polysaccharide vaccine (PPV-23) at 12 months. Strong booster effects for all 7 PCV-7 serotypes were elicited, and for 4/7 serotypes these responses were highest in the single PCV-7 group. There were fourfold rises in GMC for all non-PCV-7 serotypes. By 17 months the PPV-23 group still had significantly higher GMC (each p <0.001) for all serotypes. The PPV-23 was well tolerated and induced excellent responses for all serotypes which were greatest in the single PCV-7 group. [Copyright &y& Elsevier]

Published
2010
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