1. Halogenated cyclic peptides isolated from the sponge Corticium sp.
- Author
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Laird DW, LaBarbera DV, Feng X, Bugni TS, Harper MK, and Ireland CM
- Subjects
- Animals, Antineoplastic Agents chemistry, Antineoplastic Agents pharmacology, Drug Screening Assays, Antitumor, Fiji, Humans, Hydrocarbons, Halogenated chemistry, Hydrocarbons, Halogenated pharmacology, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Peptides, Cyclic chemistry, Peptides, Cyclic pharmacology, Antineoplastic Agents isolation & purification, Hydrocarbons, Halogenated isolation & purification, Peptides, Cyclic isolation & purification, Porifera chemistry
- Abstract
Fractionation of two Fijian specimens of the sponge Corticium sp. led to the isolation of the known active alkaloid steroid plakinamine A and two new halogenated cyclic peptides, corticiamide A (1) and cyclocinamide B (2). Structural elucidation of 1 and 2 was achieved by an extensive combination of high-field NMR and HRFT MS/MS experiments, and the absolute stereochemistry of 2 was determined by acid hydrolysis and Marfey's analysis. Corticiamide A (1) and cyclocinamide B (2) represent the first peptides to be described from the genus Corticium.
- Published
- 2007
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