1. Zika seroprevalence declines and neutralizing antibodies wane in adults following outbreaks in French Polynesia and Fiji.
- Author
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Henderson AD, Aubry M, Kama M, Vanhomwegen J, Teissier A, Mariteragi-Helle T, Paoaafaite T, Teissier Y, Manuguerra JC, Edmunds J, Whitworth J, Watson CH, Lau CL, Cao-Lormeau VM, and Kucharski AJ
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Viral blood, Blood Donors, Child, Child, Preschool, Cross-Sectional Studies, Disease Outbreaks, Fiji epidemiology, Health Surveys, Humans, Immunoglobulin G blood, Infant, Infant, Newborn, Longitudinal Studies, Middle Aged, Polynesia epidemiology, Seroepidemiologic Studies, Young Adult, Zika Virus Infection transmission, Zika Virus Infection virology, Antibodies, Neutralizing, Zika Virus immunology, Zika Virus Infection epidemiology, Zika Virus Infection immunology
- Abstract
It has been commonly assumed that Zika virus (ZIKV) infection confers long-term protection against reinfection, preventing ZIKV from re-emerging in previously affected areas for several years. However, the long-term immune response to ZIKV following an outbreak remains poorly documented. We compared results from eight serological surveys before and after known ZIKV outbreaks in French Polynesia and Fiji, including cross-sectional and longitudinal studies. We found evidence of a decline in seroprevalence in both countries over a two-year period following first reported ZIKV transmission. This decline was concentrated in adults, while high seroprevalence persisted in children. In the Fiji cohort, there was also a significant decline in neutralizing antibody titres against ZIKV, but not against dengue viruses that circulated during the same period., Competing Interests: AH, MA, MK, JV, AT, TM, TP, YT, JM, JE, JW, CW, CL, VC, AK No competing interests declared, (© 2020, Henderson et al.)
- Published
- 2020
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