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Background Moderate-to-severe psoriasis is associated with reduced health-related quality of life ( HRQoL). Individuals with psoriasis are at increased risk for other medical conditions, but little information quantifies the incremental burden of psoriasis-associated comorbidity among European adults, and data have generally been limited to clinical samples. Objective To quantify the incremental burden of cardiovascular comorbidity and psoriatic arthritis among adults with moderate-to-severe psoriasis in the general population of France, Germany, Italy, Spain and the United Kingdom ( EU5). Methods All measures were self-reported and came from the 2010-2013 EU5 National Health and Wellness Surveys ( NHWS). Moderate-to-severe psoriasis was identified by >10% body surface area affected by psoriasis and/or use of therapies for moderate-severe disease. Outcomes were SF-12v2/ SF-36v2 mental and physical component summary scores ( MCS and PCS, respectively), SF-6D health utility, Work Productivity and Activity Impairment ( WPAI) questionnaire and healthcare use in the past 6 months. Generalized linear models compared across cardiovascular comorbidity (CV) or psoriatic arthritis (PsA) groups vs. non- CV or non-PsA groups with appropriate link functions to adjust for covariates. Results Among moderate-to-severe psoriasis respondents ( n = 957), 19.8% ( n = 190) reported CV comorbidity and 12.3% ( n = 118) reported PsA. After adjustment for covariates, CV comorbidity was associated with 3.0 points lower MCS, 3.4 points lower PCS and 0.05 points lower SF-6D (all P < 0.01). Likewise, they had greater mean work impairment (48% vs. 33%), more activity impairment (48% vs. 37%), and more healthcare provider visits (8.8 vs. 6.9), emergency room visits (0.65 vs. 0.31) and hospitalizations (0.61 vs. 0.22) (all P < 0.05). Compared to non-PsA respondents, PsA respondents also had worse mean MCS (2.6 points), PCS (6.3 points) and SF-6D scores (0.07 points), and more work impairment (52% vs. 34%), activity impairment (54% vs. 38%) and healthcare provider visits (10.5 vs. 6.9) (all P < 0.05). Conclusion CV comorbidity and PsA were associated with significant incremental burden among EU5 adults with moderate-to-severe psoriasis. [ABSTRACT FROM AUTHOR]