1. Volvalerenone A, a new type of mononorsesquiterpenoid with an unprecedented 3,12-oxo bridge from Valeriana officinalis
- Author
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Wang, Peng-Cheng, Ran, Xin-Hui, Chen, Rui, Li, Liang-Chun, Xiong, Shan-Shan, Liu, Yu-Qing, Luo, Huai-Rong, Zhou, Jun, and Zhao, You-Xing
- Subjects
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SESQUITERPENES , *OXO compounds , *VALERIANA officinalis , *X-ray crystallography , *BIOSYNTHESIS , *CHOLINESTERASES , *NERVE growth factor - Abstract
Abstract: Volvalerenone A (1), a new type of mononorsesquiterpenoid with an unprecedented 5/6/6 tricyclic ring system, was isolated from the roots of Valeriana officinalis, the official species of valerian used in Europe. The structure of volvalerenone A was elucidated based on its spectroscopic and single-crystal X-ray crystallography data. The absolute configuration was assigned by the computational method. A possible biosynthetic pathway of volvalerenone A was also proposed. Preliminary biological studies showed that volvalerenone A had weak inhibitory activity on acetylcholine esterase (AChE), and no enhancing activity on nerve growth factor (NGF)-mediated neurite outgrowth in PC12 cells was observed at 50μM. [Copyright &y& Elsevier]
- Published
- 2010
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