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Overconfidence is a prevalent problem and it is particularly consequential in its relation with scientific knowledge: being unaware of one's own ignorance can affect behaviours and threaten public policies and health. However, it is not clear how confidence varies with knowledge. Here, we examine four large surveys, spanning 30 years in Europe and the United States and propose a new confidence metric. This metric does not rely on self-reporting or peer comparison, operationalizing (over)confidence as the tendency to give incorrect answers rather than 'don't know' responses to questions on scientific facts. We find a nonlinear relationship between knowledge and confidence, with overconfidence (the confidence gap) peaking at intermediate levels of actual scientific knowledge. These high-confidence/intermediate-knowledge groups also display the least positive attitudes towards science. These results differ from current models and, by identifying specific audiences, can help inform science communication strategies., (© 2023. The Author(s), under exclusive licence to Springer Nature Limited.)

Every year, influenza epidemics affect millions of people and place a strong burden on health care services. A timely knowledge of the onset of the epidemic could allow these services to prepare for the peak. We present a method that can reliably identify and signal the influenza outbreak. By combining official Influenza-Like Illness (ILI) incidence rates, searches for ILI-related terms on Google, and an on-call triage phone service, Saúde 24, we were able to identify the beginning of the flu season in 8 European countries, anticipating current official alerts by several weeks. This work shows that it is possible to detect and consistently anticipate the onset of the flu season, in real-time, regardless of the amplitude of the epidemic, with obvious advantages for health care authorities. We also show that the method is not limited to one country, specific region or language, and that it provides a simple and reliable signal that can be used in early detection of other seasonal diseases., Competing Interests: Authors MW, MMP and JGS have no conflict of interests. CL declares to have benefited from a position as the Executive Medical Director of the Portuguese Health Call Centre-S24.

Background: A debate surrounding multiple sclerosis epidemiology has centred on time-related incidence increases and the need of monitoring. The purpose of this study is to reassess multiple sclerosis incidence in the European Economic Area., Methods: We conducted a systematic review of literature from 1965 onwards and integrated elements of original research, including requested or completed data by surveys authors and specific analyses., Results: The review of 5323 documents yielded ten studies for age- and sex-specific analyses, and 21 studies for time-trend analysis of single data sets. After 1985, the incidence of multiple sclerosis ranged from 1.12 to 6.96 per 100,000 population, was higher in females, tripled with latitude, and doubled with study midpoint year. The north registered increasing trends from the 1960s and 1970s, with a historic drop in the Faroe Islands, and fairly stable data in the period 1980-2000; incidence rose in Italian and French populations in the period 1970-2000, in Evros (Greece) in the 1980s, and in the French West Indies in around 2000., Conclusions: We conclude that the increase in multiple sclerosis incidence is only apparent, and that it is not specific to women. Monitoring of multiple sclerosis incidence might be appropriate for the European Economic Area.