1. First results of the "Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS)".
- Author
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Jakob CEM, Borgmann S, Duygu F, Behrends U, Hower M, Merle U, Friedrichs A, Tometten L, Hanses F, Jung N, Rieg S, Wille K, Grüner B, Klinker H, Gersbacher-Runge N, Hellwig K, Eberwein L, Dolff S, Rauschning D, von Bergwelt-Baildon M, Lanznaster J, Strauß R, Trauth J, de With K, Ruethrich M, Lueck C, Nattermann J, Tscharntke L, Pilgram L, Fuhrmann S, Classen A, Stecher M, Schons M, Spinner C, and Vehreschild JJ
- Subjects
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Angiotensin-Converting Enzyme Inhibitors adverse effects, Body Mass Index, COVID-19 diagnosis, COVID-19 physiopathology, COVID-19 virology, Cardiovascular Diseases diagnosis, Cardiovascular Diseases physiopathology, Cardiovascular Diseases virology, Cohort Studies, Comorbidity, Diabetes Mellitus diagnosis, Diabetes Mellitus physiopathology, Diabetes Mellitus virology, Europe epidemiology, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors adverse effects, Kidney Diseases diagnosis, Kidney Diseases physiopathology, Kidney Diseases virology, Logistic Models, Lung Diseases diagnosis, Lung Diseases physiopathology, Lung Diseases virology, Male, Middle Aged, SARS-CoV-2 pathogenicity, Severity of Illness Index, Sex Factors, COVID-19 epidemiology, Cardiovascular Diseases epidemiology, Diabetes Mellitus epidemiology, Kidney Diseases epidemiology, Lung Diseases epidemiology, Pandemics
- Abstract
Purpose: Knowledge regarding patients' clinical condition at severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection is sparse. Data in the international, multicenter Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) cohort study may enhance the understanding of COVID-19., Methods: Sociodemographic and clinical characteristics of SARS-CoV-2-infected patients, enrolled in the LEOSS cohort study between March 16, 2020, and May 14, 2020, were analyzed. Associations between baseline characteristics and clinical stages at diagnosis (uncomplicated vs. complicated) were assessed using logistic regression models., Results: We included 2155 patients, 59.7% (1,287/2,155) were male; the most common age category was 66-85 years (39.6%; 500/2,155). The primary COVID-19 diagnosis was made in 35.0% (755/2,155) during complicated clinical stages. A significant univariate association between age; sex; body mass index; smoking; diabetes; cardiovascular, pulmonary, neurological, and kidney diseases; ACE inhibitor therapy; statin intake and an increased risk for complicated clinical stages of COVID-19 at diagnosis was found. Multivariable analysis revealed that advanced age [46-65 years: adjusted odds ratio (aOR): 1.73, 95% CI 1.25-2.42, p = 0.001; 66-85 years: aOR 1.93, 95% CI 1.36-2.74, p < 0.001; > 85 years: aOR 2.38, 95% CI 1.49-3.81, p < 0.001 vs. individuals aged 26-45 years], male sex (aOR 1.23, 95% CI 1.01-1.50, p = 0.040), cardiovascular disease (aOR 1.37, 95% CI 1.09-1.72, p = 0.007), and diabetes (aOR 1.33, 95% CI 1.04-1.69, p = 0.023) were associated with complicated stages of COVID-19 at diagnosis., Conclusion: The LEOSS cohort identified age, cardiovascular disease, diabetes and male sex as risk factors for complicated disease stages at SARS-CoV-2 diagnosis, thus confirming previous data. Further data regarding outcomes of the natural course of COVID-19 and the influence of treatment are required.
- Published
- 2021
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