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2 results on '"Rodríguez-Antigüedad, A."'

1. 13th Post-ECTRIMS Meeting: review of the new developments presented at the 2020 ECTRIMS Congress (I).

Author

Fernández O, Montalban X, Aladro Y, Alonso A, Arroyo R, Calles C, Castillo-Triviño T, Comabella M, Costa-Frossard L, Forero L, Ginestal R, Landete L, Llaneza M, Llufriu S, Martínez-Ginés ML, Meca-Lallana J, Mendibe M, Oreja-Guevara C, Oterino A, Prieto JM, Ramió-Torrentà L, Romero-Pinel L, Téllez N, and Rodríguez-Antigüedad A

Subjects
Biomarkers, Central Nervous System diagnostic imaging, Comorbidity, Environmental Exposure, Epigenesis, Genetic, Europe, Gray Matter pathology, Humans, Life Style, Lymphocyte Subsets immunology, Lymphoid Tissue pathology, Meninges pathology, Microbiota, Neuroglia pathology, Neurology trends, Neurons pathology, Remyelination, COVID-19 epidemiology, Multiple Sclerosis epidemiology, Multiple Sclerosis genetics, Multiple Sclerosis microbiology, Multiple Sclerosis pathology
Abstract

Introduction: For more than a decade, following the ECTRIMS Congress, the Post-ECTRIMS Meeting has been held in Spain, where neurologists with expertise in multiple sclerosis (MS) from all over the country meet to review the most relevant latest developments presented at the ECTRIMS congress (on this occasion held together with ACTRIMS)., Aim: This article, published in two parts, summarises the presentations that took place at the Post-ECTRIMS Meeting, held online on 16 and 17 October 2020., Development: This first part includes the latest results regarding the impact of the environment and lifestyle on risk of MS and its clinical course, and the role of epigenetics and genetic factors on these processes. Findings from preclinical and clinical research on the lymphocyte subtypes identified and the involvement of lymphoid follicles and meningeal involvement in the disease are discussed. Changes in brain structure are addressed at the microscopic and macroscopic levels, including results from high-resolution imaging techniques. The latest advances on biomarkers for the diagnosis and prognosis of MS, and on the involvement of the microbiome in these patients are also reported. Finally, results from patient registries on the impact of COVID-19 in MS patients are outlined., Conclusions: There have been new data on MS risk factors, the impact of MS at the cellular and structural level, the role of the microbiome in the disease, biomarkers, and the relationship between COVID-19 and MS.

Published
2021
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2. [Review of the novelties presented at the 26th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (I)].

Author

Fernández-Fernández O, Alvarez-Cermeño JC, Arbizu-Urdiain T, Arroyo-González R, Arnal-García C, Casanova-Estruch B, Calles-Hernández MC, Coret-Ferrer F, Comabella M, García-Merino JA, de Las Heras V, Izquierdo G, Meca-Lallana JE, Muñoz-García D, Olascoaga J, Oreja-Guevara C, Prieto JM, Rodríguez-Antigüedad A, Tintoré M, and Montalban X

Subjects
Biomarkers, Diagnosis, Differential, Disease Progression, Disease Susceptibility, Environment, Europe, Female, Humans, Life Style, Male, Multiple Sclerosis etiology, Multiple Sclerosis genetics, Nerve Regeneration physiology, Virus Diseases complications, Congresses as Topic, Multiple Sclerosis pathology, Multiple Sclerosis physiopathology
Abstract

The new insights presented at European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), held in the city of Gothenburg, Sweden, in October 2010, have been summarized at the third edition of Post-ECTRIMS meeting held in Madrid in November 2010. The age is an important factor related to the course and prognosis of multiple sclerosis (MS). The evolution to progressive disease persists more than 50 years after diagnosis of MS and a reduction in the delay of diagnosis has been detected. Several strategies have been proposed in order to improve the efficacy of magnetic resonance regarding prognosis and course of disease. The studies presented at the Congress reflect the influence of gender on course and severity of disease symptoms, showing an increase of worldwide prevalence of MS in women. Neuroprotective action of estrogen receptor beta has been reported. The genome wide association studies have allowed investigators to identify numerous susceptible alleles. In this regard, HLA class II genes, seems to contribute to genetic risk for developing neutralizing antibodies against beta-interferon. Vitamin D deficiency and Epstein-Barr virus have been highlighted as risk factors for MS in the reported findings. On the subject of the ongoing controversy regarding the role of inflammation and degeneration in MS, several arguments have been found to support the role of CNS autoimmunity to explain the presence of inflammatory phenomenon. The available data hold the potential therapeutic role of mesenchymal cells given the involvement of these stem cells in CNS repair.

Published
2011

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