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Transforming difficulties into opportunities for thriving is at the heart of this volume on the science of learning and development. This chapter brings the perspective of European research and the Global North and South and discusses some of the challenges included in the call to create the conditions for promoting sustainable and equitable futures for all. Among others, globalizing transformative knowledge by recreating, replicating, and scaling up success stories in education research can overcome methodological or epistemological limitations. Examples of cocreation and interdisciplinary work are included to produce socially relevant knowledge and be effective in tackling the real problems affecting children and youth. Dialogic learning and successful educational actions illustrate how educational success and transformation can happen.