1. No association between TGF-β1 polymorphisms and radiation-induced lung toxicity in a European cohort of lung cancer patients.
- Author
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Voets AM, Oberije C, Struijk RB, Reymen B, De Ruyck K, Thierens H, Vandecasteele K, De Neve W, Houben R, De Ruysscher D, Smeets HJ, and Lambin P
- Subjects
- Adult, Aged, Aged, 80 and over, Carcinoma, Non-Small-Cell Lung pathology, Carcinoma, Non-Small-Cell Lung radiotherapy, Cohort Studies, Dyspnea etiology, Europe, Female, Follow-Up Studies, Genetic Predisposition to Disease, Genotype, Humans, Lung Neoplasms pathology, Male, Middle Aged, Neoplasm Staging, Radiotherapy Dosage, Risk Factors, Small Cell Lung Carcinoma pathology, Small Cell Lung Carcinoma radiotherapy, Carcinoma, Non-Small-Cell Lung genetics, Lung Neoplasms genetics, Lung Neoplasms radiotherapy, Polymorphism, Single Nucleotide, Radiation Pneumonitis genetics, Small Cell Lung Carcinoma genetics, Transforming Growth Factor beta1 genetics
- Abstract
This study aimed at validating the previously published association between TGF-β1 single nucleotide polymorphisms and a reduced risk for radiation-induced lung toxicity. We were not able to confirm the reported association, neither using maximum dyspnea score nor after correction for baseline dyspnea score., (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2012
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