1. Traces of human migrations in Helicobacter pylori populations.
- Author
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Falush D, Wirth T, Linz B, Pritchard JK, Stephens M, Kidd M, Blaser MJ, Graham DY, Vacher S, Perez-Perez GI, Yamaoka Y, Mégraud F, Otto K, Reichard U, Katzowitsch E, Wang X, Achtman M, and Suerbaum S
- Subjects
- Africa, Agriculture, Americas, Asia, Bacterial Proteins genetics, Bayes Theorem, Ethnicity, Europe, Genes, Bacterial, Genetic Variation, Geography, Helicobacter Infections transmission, Helicobacter pylori classification, Helicobacter pylori isolation & purification, Humans, Indians, North American, Language, Polynesia, Racial Groups, Recombination, Genetic, Social Problems, Software, Emigration and Immigration, Genetics, Population, Helicobacter Infections microbiology, Helicobacter pylori genetics, Polymorphism, Genetic
- Abstract
Helicobacter pylori, a chronic gastric pathogen of human beings, can be divided into seven populations and subpopulations with distinct geographical distributions. These modern populations derive their gene pools from ancestral populations that arose in Africa, Central Asia, and East Asia. Subsequent spread can be attributed to human migratory fluxes such as the prehistoric colonization of Polynesia and the Americas, the neolithic introduction of farming to Europe, the Bantu expansion within Africa, and the slave trade.
- Published
- 2003
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