1. Intercontinental study on pre-engraftment and post-engraftment Gram-negative rods bacteremia in hematopoietic stem cell transplantation patients: Risk factors and association with mortality.
- Author
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Averbuch D, Tridello G, Hoek J, Mikulska M, Pabst T, Yaňez San Segundo L, Akan H, Özçelik T, Donnini I, Klyasova G, Botelho de Sousa A, Zuckerman T, Tecchio C, de la Camara R, Aki SZ, Ljungman P, Gülbas Z, Nicolas-Virelizier E, Calore E, Perruccio K, Ram R, Annaloro C, Martino R, Avni B, Shaw PJ, Jungova A, Codeluppi K, O'Brien T, Waszczuk-Gajda A, Batlle M, Pouli A, Lueck C, Gil L, Iacobelli S, Styczynski J, Engelhard D, and Cesaro S
- Subjects
- Aged, Asia, Australia, Europe epidemiology, Europe, Eastern, Humans, Prospective Studies, Retrospective Studies, Risk Factors, Transplantation, Homologous, Bacteremia epidemiology, Hematopoietic Stem Cell Transplantation adverse effects
- Abstract
Objectives: We present here data on Gram-negative rods bacteremia (GNRB) rates, risk factors and associated mortality., Methods: Data on GNRB episodes were prospectively collected in 65 allo-/67 auto-HSCT centers in 24 countries (Europe, Asia, Australia). In patients with and without GNRB, we compared: demography, underlying disease, HSCT-related data, center` fluoroquinolone prophylaxis (FQP) policy and accreditation status, and involvement of infection control team (ICT)., Results: The GNRB cumulative incidence among 2818 allo-HSCT was: pre-engraftment (pre-eng-allo-HSCT), 8.4 (95% CI 7-9%), post-engraftment (post-eng-allo-HSCT), 5.8% (95%CI: 5-7%); among 3152 auto-HSCT, pre-eng-auto-HSCT, 6.6% (95%CI: 6-7%), post-eng-auto-HSCT, 0.7% (95%CI: 0.4-1.1%). GNRB, especially MDR, was associated with increased mortality. Multivariate analysis revealed the following GNRB risk factors: (a) pre-eng-allo-HSCT: south-eastern Europe center location, underlying diseases not at complete remission, and cord blood source; (b) post-eng-allo-HSCT: center location not in northwestern Europe; underlying non-malignant disease, not providing FQP and never accredited. (c) pre-eng-auto-HSCT: older age, autoimmune and malignant (vs. plasma cell) disease, and ICT absence., Conclusions: Benefit of FQP should be explored in prospective studies. Increased GNRB risk in auto-HSCT patients transplanted for autoimmune diseases is worrying. Infection control and being accredited are possibly protective against bacteremia. GNRB are associated with increased mortality., Competing Interests: Declarations of Competing Interest HA declares receiving a research grant from MSD; speaker grant from Gilead, MSD, Pfizer. Other co-authors have no conflicts of interest to declare relevant to this study., (Copyright © 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2020
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