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Summarizes the scientific presentations during the ZINCAGE meeting, a European Union Sixth Framework project involving several European research groups, which will study biochemical, genetic and lifestyle factors for healthy aging with a particular focus on nutritional zinc, oxidative stress and immunosenescence. Authors of the studies; Features of the project.

Since associations between lifespan and certain simple immune parameters such as T cell proliferative responses to mitogens were reported in the 1970´s, efforts to dissect out immune parameters correlating with morbidity and mortality have sought to define factors predicting individual longevity. Such "immune signatures" associating with defined clinical outcomes would represent biomarkers of "immunosenescence" that might also provide mechanistic insights into the ageing process. Because appropriate immune function is necessary for a healthy old age, a better understanding of immunosenescence contributing to frailty and death might allow interventions to improve personal and public health. Here, we discuss data from our studies in several different European countries and document significant differences between overtly similar populations. These findings draw attention to the marked variation even between presumably quite homogeneous populations, which may be due to the different birth cohorts studied in addition to numerous other variables. Thus, immunological parameters, and presumably many other factors, are sensitive to context-dependent variation, making it currently difficult to extrapolate biomarkers of longevity from any one human population to another., (Copyright © 2018 Elsevier B.V. All rights reserved.)

The European Searchable Tumour line Database (ESTDAB) ( http://www.ebi.ac.uk/ipd/estdab ) is a freely available and fully searchable database of melanoma-derived cell lines, which have been characterised for over 250 immunologically relevant markers by a consortium of European scientists. The database is linked to a cell bank, which can provide melanoma cell lines to non-profit investigators for a nominal handling charge. All cells are fully HLA typed at the genomic and surface expression levels. The expression of a number of surface antigens, apoptotic markers, tumour-associated antigens and extracellular matrix proteins has also been determined. Cytokine secretion has been tested and polymorphisms in cytokine genes have been identified. Glycans at the cell surface were identified and glycosyltransferase activity quantified. Cell lines with a particular constellation of these parameters can be sought online via the ESTDAB interface, which is included as part of the Immuno-Polymorphism Database (IPD) section of the European Bioinformatics Institute's (EBI) website.