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1. The current scientific and legal status of alternative methods to the LD50 test for botulinum neurotoxin potency testing. The report and recommendations of a ZEBET Expert Meeting.

Author

Adler S, Bicker G, Bigalke H, Bishop C, Blümel J, Dressler D, Fitzgerald J, Gessler F, Heuschen H, Kegel B, Luch A, Milne C, Pickett A, Ratsch H, Ruhdel I, Sesardic D, Stephens M, Stiens G, Thornton PD, Thürmer R, Vey M, Spielmann H, Grune B, and Liebsch M

Subjects
Acetylcholine antagonists & inhibitors, Animal Testing Alternatives legislation & jurisprudence, Animals, Diaphragm drug effects, Diaphragm physiology, Europe, Lethal Dose 50, Mice, Nerve Endings drug effects, Nerve Endings physiology, Neuromuscular Junction drug effects, Reproducibility of Results, Animal Testing Alternatives methods, Botulinum Toxins toxicity, Neuromuscular Junction physiology
Published
2010
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