1. A molecular basis for target-cell toxicity and upper urothelial carcinoma in analgesic abusers and patients with Balkan endemic nephropathy.
- Author
-
Bach PH
- Subjects
- Animals, Butylhydroxybutylnitrosamine analogs & derivatives, Butylhydroxybutylnitrosamine toxicity, Carcinogenicity Tests, Carcinogens toxicity, Cocarcinogenesis, Epithelium drug effects, Epithelium pathology, Europe epidemiology, FANFT toxicity, Humans, Hyperplasia, Incidence, Kidney Neoplasms epidemiology, Models, Biological, Mycotoxicosis complications, Mycotoxicosis epidemiology, Ochratoxins adverse effects, Ochratoxins toxicity, Precancerous Conditions chemically induced, Precancerous Conditions pathology, Rats, Rats, Inbred Strains, Rodentia, Smoking adverse effects, Substance-Related Disorders complications, Ureteral Neoplasms epidemiology, Analgesics adverse effects, Balkan Nephropathy, Disease Models, Animal, Kidney Neoplasms chemically induced, Kidney Papillary Necrosis chemically induced, Ureteral Neoplasms chemically induced
- Abstract
Ochratoxin A is ubiquitous in regions where Balkan endemic nephropathy is common. It damages the kidney cortex in a range of experimental animals and induces renal parenchymal carcinoma in mice, but it is not a potent carcinogen, nor is there experimental evidence to link it to upper urothelial carcinoma (UUC). A model UUC can be induced experimentally in rodents by urothelial initiation, followed by an acutely induced papillary necrosis. This two-stage experimental model may help to clarify the role of ochratoxin A in initiating or promoting upper urothelial cells and increase our understanding of the development of UUC in patients with Balkan endemic nephropathy.
- Published
- 1991