Search

Background Several mumps outbreaks have been reported in Europe and in the United States among highly vaccinated populations. Biological diagnosis is classically based on the detection of mumps-specific IgM, but the ability of serological tests to confirm mumps infection seems to be limited among vaccinated patients. Objectives We aim to report a mumps outbreak in an engineering school in Grenoble, France, from February to June 2013 and results of the biological testing. Study design WHO definitions were used to define cases. Mumps – specific IgM and IgG were assessed by a commercially available EIA. Mumps RNA detection by real time reverse transcriptase polymerase chain reaction tests (RT-PCR) and mumps genotyping were performed by the French National Reference Centre for Paramyxoviridae. Results Sixty two mumps patient-cases were identified using WHO case definitions, 20 being biologically explored, of which 17 were confirmed by biological tests. Vaccination status was documented for 27 patients/62: 4 (14.8%) patients had received one dose of MMR vaccine, and 23 (85.2) two doses of MMR vaccine. Among the biologically explored patients, 83% had a positive RT PCR at the first sampling whereas only 45% had positive or equivocal IgM. All the genotyped strains were genotype G. Conclusions Mumps laboratory diagnosis in a highly vaccinated population is challenging. Serological tests among vaccinated patients should be interpreted cautiously and confirmed by RT-PCR tests at the beginning of a mumps outbreak. [ABSTRACT FROM AUTHOR]

Purpose: The following investigation aims to highlight strengths and weaknesses of the computer science degree from the part of students. Design/methodology/approach: This paper presents the results of a quantitative investigation that sheds light on student's motivations to pursue or reject computer science. Findings: The study identified the reasons that cause this rejection and suggest them as opportunities to enhance the domain in the future. Practical implications: This study is a preliminary phase of a larger research goal which aims to identify the strategies presented to computer science education using technology to foster interest in the domain among students and professionals in Europe. Originality/value: The declining number of computer science students in Europe is producing negative consequences in the technology field that affect other sectors like the economic and educational ones. In order to analyze this situation and in view of providing solutions to stop the decline, it is primordial to understand the reasons that retain students to choose this domain of study or that attract and retain them in the field. [ABSTRACT FROM AUTHOR]

A series of tests were conducted under laboratory conditions to assess, first, the capacity of several fuel beds to be ignited by firebrands and to sustain a fire and, second, the capability of different types of firebrands to ignite fuel beds. Fuel beds and firebrands were selected among the most common in southern Europe. Regarding fuel bed flammability, results show that grasses are more flammable than litter and, among litters, Pinus species are the most flammable. The increase in bulk density and fuel moisture content involves an increase in the time to ignition, and a decrease in the other flammability parameters. The capability of firebrands to ignite fuel beds is higher when the firebrands drop in the flaming phase and with no air flow than in glowing phase with air flow. Logistic regression models to predict fuel bed ignition probability were developed. As a whole, results show a relationship between ignition probability of fuel bed and type or weight of firebrands. Pinus pinaster cone scale, P. halepensis cone scale, and Eucalyptus globulus leaf and bark can have ignition probabilities at least twice higher than pine bark when falling while in flaming combustion. [ABSTRACT FROM AUTHOR]

Neurocognitive disorders causing progressive cognitive, functional, and behavioral impairment remain underdiagnosed. The needs for a timely diagnosis are now widely acknowledged since person-centered care helps to preserve life quality and prevent crises. One powerful barrier to detection in primary care is the lack of an easy-to-follow stepwise approach, grounded in evidence and consistent with high-quality specialty practice. To help fill this gap, the current European Joint Action proposes a graduated diagnosis strategy tailored to the patients' needs and wills, clarifying appropriate components for primary and specialty care. This strategy considers a first evaluation in primary care that may detect a neurocognitive disorder, that would lead to a second evaluation step allowing etiological diagnosis hypotheses performed mostly by the specialist. A third evaluation stage considering some biological, electrophysiological, or neuroimaging complementary techniques would be proposed to atypical cases or patients willing to consider access to research. [ABSTRACT FROM AUTHOR]

One of the first reports on the state of medical education was published in 1910 in North America, with the support of the Carnegie Foundation, showing that the interest for this issue dates back at least a century. Doctors (and nurses) are among the few professionals who managed to avoid for a long time any sort of evaluation of their knowledge and competence after the achievement of their diploma. But concern has been rising in society about the fast obsolescence of medical knowledge, particularly in the last 50 years when the development of research and technology in the field has been so fast. The concept of Continuing Medical Education gained growing interest after the Second World War as a necessity for health professionals, but also as a form of protection of patients, who have the right to be treated by competent and knowledgeable doctors and nurses. The United States (US)-based Josiah Macy Foundation recently sponsored a conference exploring the state of continuing education and the result is ‘a picture of a disorganised system of education with obvious foci of excellence (most in universities) but with most commercially supported events shading more towards product promotion and the welfare of doctors than prioritised dedication to enhancing the care of patients’. Despite the fact that there is a lot to be learned from the US experience, Europe has to find its own way. Considerable progress was made since 1995 when UEMS (Union Européenne des Médecins Spécialistes) started to structure CME activities in Europe at translational level. A workshop on the issue was jointly organised by the European School of Oncology (ESO) and the Accreditation Council of Oncology in Europe (ACOE) in Berlin in September 2009. [Copyright &y& Elsevier]

Columbus, the European Space Agency (ESA) orbital facility laboratory will be launched in December 2007 and attached to the International Space Station (ISS). In its launch configuration, Columbus includes 4 multi-user facilities: one of them is the European Physiology Modules Facility, also called EPM. The EPM will be devoted to Human Physiology; it will be collocated in the Columbus module with two other physiology racks, i.e. the HRF-1 and HRF-2 American racks (Human Research Facility). CADMOS is part of the French Space Agency, located in Toulouse; it has been designated by the European Space Agency as the Facility Responsible Centre (FRC) for the EPM. As a User Support and Operations Centre, CADMOS main tasks are to help the scientists to prepare and perform their experiments in Space and to monitor operations on the ISS.

The European Space Agency has recently initiated a study of the human responses, limits and needs with regard to the stress environments of interplanetary and planetary missions. Emphasis has been laid on human health and performance care as well as advanced life support developments including bioregenerative life support systems and environmental monitoring. The overall study goals were as follows: (i) to define reference scenarios for a European participation in human exploration and to estimate their influence on the life sciences and life support requirements; (ii) for selected mission scenarios, to critically assess the limiting factors for human health, wellbeing, and performance and to recommend relevant countermeasures; (iii) for selected mission scenarios, to critically assess the potential of advanced life support developments and to propose a European strategy including terrestrial applications; (iv) to critically assess the feasibility of existing facilities and technologies on ground and in space as testbeds in preparation for human exploratory missions and to develop a test plan for ground and space campaigns; (v) to develop a roadmap for a future European strategy towards human exploratory missions, including preparatory activities and terrestrial applications and benefits. This paper covers the part of the HUMEX study dealing with lunar missions. A lunar base at the south pole where long-time sunlight and potential water ice deposits could be assumed was selected as the Moon reference scenario. The impact on human health, performance and well being has been investigated from the view point of the effects of microgravity (during space travel), reduced gravity (on the Moon) and abrupt gravity changes (during launch and landing), of the effects of cosmic radiation including solar particle events, of psychological issues as well as general health care. Countermeasures as well as necessary research using ground-based test beds and/or the International Space Station have been defined. Likewise advanced life support systems with a high degree of autonomy and regenerative capacity and synergy effects were considered where bioregenerative life support systems and biodiagnostic systems become essential. Finally, a European strategy leading to a potential European participation in future human exploratory missions has been recommended., (c2003 COSPAR. Published by Elsevier Ltd. All rights reserved.)