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Simple Summary: Mutations in the FANCM gene may cause a particular type of breast cancer known as ER-negative. In this study, we describe the geographic distribution of 66 different FANCM mutations identified in 44,803 female breast cancer cases from Europe, USA, Canada and Australia. We found that the FANCM:p.Gln1701* mutation is most common in Northern Europe and has lower frequencies in Southern European countries. In contrast, the FANCM:p.Gly1906Alafs*12 mutation is most common in Southern Europe and rarer in Central and Northern Europe. We found that the FANCM:p.Arg658* mutation is most prevalent in Central Europe and that the FANCM:p.Gln498Thrfs*7 mutation originates from Lithuania. Finally, we showed that many and varied FANCM mutations are present in Southwestern and Central Europeans while a much more limited range of mutations is present in Northeastern Europeans. The knowledge of this geographic distribution of FANCM mutations is important to establish more efficient genetic testing strategies in specific populations. FANCM germline protein truncating variants (PTVs) are moderate-risk factors for ER-negative breast cancer. We previously described the spectrum of FANCM PTVs in 114 European breast cancer cases. In the present, larger cohort, we report the spectrum and frequency of four common and 62 rare FANCM PTVs found in 274 carriers detected among 44,803 breast cancer cases. We confirmed that p.Gln1701* was the most common PTV in Northern Europe with lower frequencies in Southern Europe. In contrast, p.Gly1906Alafs*12 was the most common PTV in Southern Europe with decreasing frequencies in Central and Northern Europe. We verified that p.Arg658* was prevalent in Central Europe and had highest frequencies in Eastern Europe. We also confirmed that the fourth most common PTV, p.Gln498Thrfs*7, might be a founder variant from Lithuania. Based on the frequency distribution of the carriers of rare PTVs, we showed that the FANCM PTVs spectra in Southwestern and Central Europe were much more heterogeneous than those from Northeastern Europe. These findings will inform the development of more efficient FANCM genetic testing strategies for breast cancer cases from specific European populations. [ABSTRACT FROM AUTHOR]

Ageing Europeans are today healthier than previous generations and often manage to live independently up to a high age. The proportion of people 80 years of age and older has increased significantly, and with high age the risk of multi-illness and dementia increases. Strong urbanisation processes have changed the demographic structure in rural areas, and young women and men have migrated towards the urban areas to study and work, while older persons have remained behind. This demographic challenge of increasing numbers of persons older than 80 years with care needs living in remote rural areas has become a major European social problem. In tackling this dilemma, many European countries have high expectations for eHealth, digitalisation and welfare technology. In this comparative study of policy debates in Italy, Finland and Sweden, we analyse how – between 2009 and 2019 – the issues of eHealth have been articulated in national and regional policies of the three countries with deep differences in terms of digitalisation and health systems, but with similar ageing populations. We identify in the documents three core topics – the role of technology, the rural issue and responsibility for care. These topics are treated in the documents with differences and similarities between the three countries. Beyond the differences and similarities, the documents reveal both a certain techno-enthusiasm about the role of eHealth in the life of the older adults as well as a limited understanding of the complexity (relationally as well as spatially) of the digital landscape of caring for older adults. [ABSTRACT FROM AUTHOR]

Background: Understanding the processes that lead to hybridization of wolves and dogs is of scientific and management importance, particularly over large geographical scales, as wolves can disperse great distances. However, a method to efficiently detect hybrids in routine wolf monitoring is lacking. Microsatellites offer only limited resolution due to the low number of markers showing distinctive allele frequencies between wolves and dogs. Moreover, calibration across laboratories is time-consuming and costly. In this study, we selected a panel of 96 ancestry informative markers for wolves and dogs, derived from the Illumina CanineHD Whole-Genome BeadChip (174 K). We designed very short amplicons for genotyping on a microfluidic array, thus making the method suitable also for non-invasively collected samples. Results: Genotypes based on 93 SNPs from wolves sampled throughout Europe, purebred and non-pedigree dogs, and suspected hybrids showed that the new panel accurately identifies parental individuals, first-generation hybrids and first-generation backcrosses to wolves, while second- and third-generation backcrosses to wolves were identified as advanced hybrids in almost all cases. Our results support the hybrid identity of suspect individuals and the non-hybrid status of individuals regarded as wolves. We also show the adequacy of these markers to assess hybridization at a European-wide scale and the importance of including samples from reference populations. Conclusions: We showed that the proposed SNP panel is an efficient tool for detecting hybrids up to the third-generation backcrosses to wolves across Europe. Notably, the proposed genotyping method is suitable for a variety of samples, including non-invasive and museum samples, making this panel useful for wolf-dog hybrid assessments and wolf monitoring at both continental and different temporal scales. [ABSTRACT FROM AUTHOR]

Background and objective: The European consortium project TRANSPOSE (TRANSfusion and transplantation: PrOtection and SElection of donors) aimed to assess and evaluate the risks to donors of Substances of Human Origin (SoHO), and to identify gaps between current donor vigilance systems and perceived risks. Materials and methods: National and local data from participating organizations on serious and non‐serious adverse reactions in donors were collected from 2014 to 2017. Following this, a survey was performed among participants to identify risks not included in the data sets. Finally, participants rated the risks according to severity, level of evidence and prevalence. Results: Significant discrepancies between anticipated donor risks and the collected data were found. Furthermore, many participants reported that national data on adverse reactions in donors of stem cells, gametes, embryos and tissues were not routinely collected and/or available. Conclusions: These findings indicate that there is a need to further develop and standardize donor vigilance in Europe and to include long‐term risks to donors, which are currently underreported, ensuring donor health and securing the future supply of SoHO. [ABSTRACT FROM AUTHOR]

• Wind-driven rain (WDR) quantification experimentally on 2 case buildings. • Effect of WDR on hygrothermal conditions in internally insulated masonry studied. • Numerical simulations to determine WDR effect on hygrothermal performance. • WDR models were found to overestimate WDR deposition. • Direct influence of WDR events on RH behind insulation was not detected. An inevitable measure when energy retrofitting historic buildings in Europe, is the reduction of building envelope heat loss. On preservation-worthy facades where external insulation is not an option, installation of internal insulation is gaining pace. The historic buildings in Denmark are often constructed with solid masonry facades and wooden decks. The internal insulation may, however, entail potential hygrothermal risks in walls and embedded wood. Measures such as vapour barriers and capillary active insulation materials are continuously evolving and the subject of much current research. The hygrothermal conditions are of great importance for the durability of the building constructions, and for the health and wellbeing of occupants. Wind-driven rain (WDR) is a central factor contributing to water penetration and moisture loads of the exterior walls. Numerous studies have shown that WDR loads influence the moisture conditions in masonry walls and embedded wooden beams, and can even affect interior relative humidity. In the present paper WDR loads on existing façades in a cold temperate climate were determined by measurements and compared to a semi-empirical model. Simultaneously, the hygrothermal conditions within internally insulated walls with exposed brick and embedded wooden beams were monitored. Furthermore, numerical simulations were implemented for clarification of WDR impact. Hygrothermal simulations and previous studies, inevitably show that high WDR loads result in higher moisture content behind the interior insulation. Results from the field measurements of WDR however, cannot directly be referred to the moisture content measured in walls behind interior insulation or beam ends. However, fluctuations in external air humidity proved to be influential on condiditons in the construction. Implementation of a semi-empirical model for calculations of WDR agreed with previous studies in predictions being too conservative when compared to measured WDR. [ABSTRACT FROM AUTHOR]

BACKGROUND: The assessment of bone age and skeletal maturity and its comparison to chronological age is an important task in the medical environment for the diagnosis of pediatric endocrinology, orthodontics and orthopedic disorders, and legal environment in what concerns if an individual is a minor or not when there is a lack of documents. Being a time-consuming activity that can be prone to inter- and intra-rater variability, the use of methods which can automate it, like Machine Learning techniques, is of value. OBJECTIVE: The goal of this paper is to present the state of the art evidence, trends and gaps in the research related to bone age assessment studies that make use of Machine Learning techniques. METHOD: A systematic literature review was carried out, starting with the writing of the protocol, followed by searches on three databases: Pubmed, Scopus and Web of Science to identify the relevant evidence related to bone age assessment using Machine Learning techniques. One round of backward snowballing was performed to find additional studies. A quality assessment was performed on the selected studies to check for bias and low quality studies, which were removed. Data was extracted from the included studies to build summary tables. Lastly, a meta-analysis was performed on the performances of the selected studies. RESULTS: 26 studies constituted the final set of included studies. Most of them proposed automatic systems for bone age assessment and investigated methods for bone age assessment based on hand and wrist radiographs. The samples used in the studies were mostly comprehensive or bordered the age of 18, and the data origin was in most of cases from United States and West Europe. Few studies explored ethnic differences. CONCLUSIONS: There is a clear focus of the research on bone age assessment methods based on radiographs whilst other types of medical imaging without radiation exposure (e.g. magnetic resonance imaging) are not much explored in the literature. Also, socioeconomic and other aspects that could influence in bone age were not addressed in the literature. Finally, studies that make use of more than one region of interest for bone age assessment are scarce. [ABSTRACT FROM AUTHOR]

Historically, there has been much confusion surrounding the identity and separation of European and North American species of Glossiphonia (Annelida: Clitellata: Glossiphoniidae). Using cytochrome c oxidase subunit I (COI) sequences from newly collected specimens of Glossiphonia complanata and Glossiphonia elegans from a broad geographic range covering southern Canada, parts of the US, Slovenia and Croatia, we confirm that G. complanata is likely confined to Europe. The species is phylogenetically distinct from G. elegans, which seems to exclusively inhabit North America. Parsimony and maximum likelihood of the COI locus show the European samples placing as the sister group to an unidentified species of Glossiphonia from Russia, while the North American samples are the sister group to all other Glossiphonia species. We also investigate the consistency of number of crop cecae for separating these species and contrary to previous reports, this character shows no differences between our specimens of the two species. Additionally, the trees show evidence of subdivisions within both G. complanata and G. elegans, with some sequences separated by high 'intraspecific' distances. Forces might be shaping population structure and/or potential incipient speciation within these species, emphasizing the need for future research into the biogeography and population genetics of Glossiphonia. [ABSTRACT FROM AUTHOR]

In Europe, concerns regarding the provision of ecosystem services from forests, such as biodiversity, has led to a widespread conversion from even-aged to close-to-nature forest management. These concerns have also led to a demand for quantifying stand structure, dynamics, and species diversity in order to evaluate ecosystem status and devise management action. In this study, species distribution, species association, and size diversity in a semi-natural, unmanaged beech forest in Denmark were analyzed using spatial indices including uniform angle index, mingling index, and differentiation index and spatial functions including pair correlation function, bivariate pair correlation function, mark variogram, and the Wiegand scheme. To analyze the spatial patterns of tree species, two plots, one in a less disturbed part of the forest and the other in a more recently disturbed part, was selected. Based on the spatial functions, all species showed a clustered pattern as a result of forest dynamics. Fagus sylvatica L. was segregated from other species and was more likely to form pure groups. In contrast, Ulmus glabra L.- Fraxinus excelsior L. and Ulmus glabra L.- Acer psedoplatanous L. showed positive association. All species in the less disturbed part of the forest showed positive spatial correlation of tree diameters, probably as a result of gap-phase dynamics. However, a lack of spatial correlation of tree diameters was observed for beech and elm trees in the more recently disturbed part of the forest. Our results indicated that spatial functions using stem-mapped data provide more reliable results and additional insights into the stand structure than neighborhood based indices. The study findings can be used to align forest management practices with goals of protecting biodiversity in managed forest. [ABSTRACT FROM AUTHOR]

Purpose To develop and perform reliability and validity assessments of the international Multidimensional Nursing Generations Questionnaire. Background There are three generations of nurses in the European workforce. There is little research on the characteristics of these generations and the ways in which to manage them professionally, and no instrument has yet been developed to measure these aspects specifically. Methods With results from previous studies, 69 nursing generations-oriented items were created in English, translated into Italian and Finnish, and pretested to form the basis of an instrument that was tested between September and October 2014 on a sample of Finnish and Italian nurses ( n = 1302) using principal component analysis and Cronbach's alpha. Results Fifty-four items and eight components (Cronbach's α range: 0.61-0.81) were identified in the instrument: (1) conflicts between generations; (2) patient safety view; (3) relationships between generations; (4) working as a multigenerational team; (5) orientation to change; (6) presenteeism and job propensity; (7) intention to leave, and (8) flexibility and availability. Conclusions The instrument showed acceptable preliminary psychometric properties and satisfactory internal consistency. Implications for nursing management The Multidimensional Nursing Generations Questionnaire is a useful tool to measure the characteristics of different generations of nurses and to develop management strategies tailored to those generations. [ABSTRACT FROM AUTHOR]

In this introduction to the special issue, we review the various debates spurred by Esping-Andersen’s The Three Worlds of Welfare Capitalism. Tracing its impact since the book’s publication in 1990, we show that Three Worlds continues to be the point of reference for comparative welfare state research. A content analysis of articles in the Journal of European Social Policy citing the book indicates that Three Worlds may even have obtained a paradigmatic status and that its claims and findings are often taken for granted rather than challenged. We conclude that Three Worlds has become a classic that is likely to continue to have a major influence on welfare state research in its next 25 years. [ABSTRACT FROM AUTHOR]

We sequenced the control region of the mitochondrial DNA from a sample of six European blue tit populations to investigate the phylogeography of Parus species. Along a transect from Barcelona, Spain to Oulu, Finland, the blue tit showed a different phylogeographic structure than the great tit and the willow tit. The southernmost sample from Barcelona consisted of two widely divergent maternal lineages (nucleotide divergence, π = 0.30%), a situation also found earlier in the French Alps. The more northern populations had a relatively uniform structure (π = 0.19%) with distinctive marks of a growing population, thus resembling the great tit populations (π = 0.19%). The amount of genetic variation among blue tits is lower than in the willow tit (π = 0.53%). This probably reflects a smaller long-term effective population size in the great tit and the blue tit than in the willow tit. The different genetic structure of the Barcelona population vs. the rest had an influence on the estimated population parameters, which are calculated based on the assumptions of genetic equilibrium of the populations. [ABSTRACT FROM AUTHOR]

This paper offers a theoretical and empirical contribution to our understanding of the changing European social models in wake of the economic crisis and the promotion of social investments by the European Commission. Theoretically, the article provides a conceptual framework for comparative macro-analysis of social investments that takes into account how social investment policies and returns vary over the life-course and are interdependent. Empirically, the article uses this conceptual framework to examine whether EU policy strategies and national welfare reforms follow a social investment approach. Analysing developments of social investment strategies and policies in three life-stages, the article finds that many EU strategies embody elements of a social investment strategy whereas the impact of the crisis on the national level differs across countries, life-stages, and policies. In most countries, the overall policy impact of the crisis seems to be small on childcare coverage, large on youth polarization, and to increase retirement ages. The crisis will be felt in years to come with reduced life-income for younger cohorts, lower fertility laying the ground for intergenerational conflicts, and migration of skilled youth implying returns of social investments made in southern parts of Europe benefitting northern parts. That said, the overall evidence points towards social investments taking a larger role in Europe after the crisis. However, the result is unlikely to become a uniform European social investment model as the countries most in need of social investments are also the countries least likely to develop high-quality social investments. [ABSTRACT FROM PUBLISHER]

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In many European countries different types of policy reforms intending to encourage growth in the domestic service sector have been introduced. The methods and reforms differ but mainly the reforms intend to stimulate growth of a 'new' legal labour market sector within private households. This potential growth sector in combination with insufficient or declining welfare states, inclining female labour market participation and ageing populations could be viewed as explanatory factors to the increased demand for domestic services. A growing amount of those performing paid domestic work in European homes are migrant women with or without papers. The aim of this article is to create a model that enables comparisons of these reforms, with a special focus on changing social organizations of care for elders, children and other dependent persons. Included in the analysis are European countries that have introduced wide domestic service policy reforms as measurement to encourage growth in the domestic service sector, i.e. Austria, Belgium, Denmark, Finland, France, Germany and Sweden. [ABSTRACT FROM AUTHOR]

As more and more political institutions stress the significance of gender equality policies, it becomes important to investigate the different interpretations and meanings attached to the concept of gender equality in diverse policy contexts. In this article we are interested in problematizing visions of gender equality by studying the challenges that the growing amount of paid domestic work performed within European households poses for gender equality policies and practices in two European countries. The aim is to reveal normative assumptions and silences in relation to gender equality by comparing how “paid domestic work” has been framed in policy debates in Sweden and Spain. As welfare states, Sweden and Spain are generally considered to be very different, and in policies on care for children and the elderly the differences are perhaps most apparent. In both countries, however, paid domestic work in the home has become more and more common in the last two decades. The rise of paid domestic services in European households has been interpreted as due to the limitations or decline of welfare states, the ageing populations, and the increasing numbers of dual-earner families. These services are most often provided by women, predominantly of immigrant background, and involve a wide range of tasks, including care work. The phenomenon of an increasing sector of domestic (care) work poses a theoretical and methodological challenge to gender and welfare studies. This article argues that the analysis of debates surrounding domestic service in private households is a useful starting-point for an intersectional analysis by means of revealing the normative assumptions and marginalization embedded in gender equality policies. It uses a comparative frame analysis in combination with intersectional analysis to assess how interactions between gender, class, race, and sexuality have been articulated in the policy debates on domestic services in Spain and Sweden. [ABSTRACT FROM AUTHOR]

For the last 13 years, the fur industry in Europe has suffered from epidemic spouts of a severe necrotizing pyoderma. It affects all species currently farmed for fur and causes animal welfare problems and significant losses to the farmers. The causative agent of this disease was identified as Arcanobacterium phocae. Previously, this bacterium has been isolated from seals and other marine mammals, apparently causing wound and lung infections. Attempts at antibiotic treatment have been unsuccessful and the current advice on preventing the disease is to cull all animals with clinical signs. This poses an urgent question regarding possible vaccine development, as well as the need for further understanding of the pathogenicity of this organism. This study compared the whole genomes of 42 A. phocae strains isolated from seals, blue foxes, finnraccoons, mink and otter. The sequences were created using the Illumina technology and annotations were done using the RAST pipeline. A phylogenetic analysis identified a clear separation between the seal strains and the fur-animal-derived isolates, but also indicated that the bacterium readily adapts to new environments and host species with reasonable diversity. A pan- and core-genome was created and analyzed for proteins. A further analysis identified several virulence factors as well as multiple putative and secreted proteins of special interest for vaccine development. [ABSTRACT FROM AUTHOR]

The colonization history and present-day population structure of the European subspecies of the great tit Parus major major were studied using mitochondrial control region sequences. One major haplotype was found in all but one of the eight sampled populations from Spain to northern Finland. The other haplotypes differed from the common one by just a few substitutions; the overall nucleotide diversity was 0.00187 and haplotype diversity 0.8633. No population structuring was detected. The mismatch distribution followed the expected distribution of an expanding population. The estimated time to the most recent common ancestor coincides with the last glacial period. The results suggest that P. m. major survived the last glacial period in a single isolated refuge probably by the Mediterranean Sea. This was followed by rapid colonization of the European continent and population growth. The most recent range expansion northwards is still occurring. Gene flow between the sampled populations is extensive. It is aided by juvenile dispersal, long-distance movements of juvenile flocks and partial migration in the northern parts of the great tit’s range. [ABSTRACT FROM AUTHOR]

Germline protein truncating variants (PTVs) in the FANCM gene have been associated with a 2–4-fold increased breast cancer risk in case-control studies conducted in different European populations. However, the distribution and the frequency of FANCM PTVs in Europe have never been investigated. In the present study, we collected the data of 114 European female breast cancer cases with FANCM PTVs ascertained in 20 centers from 13 European countries. We identified 27 different FANCM PTVs. The p.Gln1701* PTV is the most common PTV in Northern Europe with a maximum frequency in Finland and a lower relative frequency in Southern Europe. On the contrary, p.Arg1931* seems to be the most common PTV in Southern Europe. We also showed that p.Arg658*, the third most common PTV, is more frequent in Central Europe, and p.Gln498Thrfs*7 is probably a founder variant from Lithuania. Of the 23 rare or unique FANCM PTVs, 15 have not been previously reported. We provide here the initial spectrum of FANCM PTVs in European breast cancer cases. [ABSTRACT FROM AUTHOR]

• Key message A dataset of forest resource projections in 23 European countries to 2040 has been prepared for forest-related policy analysis and decision-making. Due to applying harmonised definitions, while maintaining country-specific forestry practices, the projections should be usable from national to international levels. The dataset can be accessed at 10.5061/dryad.4t880qh. The associated metadata are available at https://metadata-afs.nancy.inra.fr/geonetwork/srv/eng/catalog.search#/metadata/8f93e0d6-b524-43bd-bdb8-621ad5ae6fa9. [ABSTRACT FROM AUTHOR]