1. Frequency of occurrence and antimicrobial susceptibility of Gram-negative bacteremia isolates in patients with urinary tract infection: results from United States and European hospitals (2009-2011).
- Author
-
Sader HS, Flamm RK, and Jones RN
- Subjects
- Bacteremia drug therapy, Enterobacter, Escherichia coli, Europe epidemiology, Gram-Negative Bacteria, Gram-Negative Bacterial Infections drug therapy, Hospitals statistics & numerical data, Humans, Klebsiella, Microbial Sensitivity Tests, Proteus mirabilis, Pseudomonas aeruginosa, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, United States epidemiology, Bacteremia epidemiology, Drug Resistance, Microbial, Gram-Negative Bacterial Infections epidemiology, Urinary Tract Infections drug therapy, Urinary Tract Infections microbiology
- Abstract
We evaluated the frequency of occurrence and antimicrobial susceptibility patterns of Gram-negative bacteria isolated from bacteremic patients with UTI from European (EU) and United States (USA) hospitals during a 3-year period (2009-2011). Susceptibility testing was performed by the reference broth microdilution method on 2071 Gram-negative bacilli. The most frequently isolated pathogens were Escherichia coli (63·3/71·3% in USA/EU), Klebsiella spp. (16·7/11·2%) and Proteus mirabilis (6·4/5·0%). Escherichia coli susceptibility rates were generally similar in the USA and EU, with extended-spectrum beta-lactamase (ESBL)-phenotype rates at 8·1% in both regions. Among Klebsiella spp., ESBL rates varied from 11·4/17·1% in 2009 to 16·1/40·4% in 2011 in USA/EU, and susceptibility rates were generally lower in EU compared to the USA. Pseudomonas aeruginosa exhibited lower susceptibility rates to ceftazidime, meropenem and piperacillin/tazobactam in EU (78·4, 78·4 and 76·5%, respectively) compared to USA (91·2, 88·2 and 91·2%, respectively). In summary, very few antimicrobials provided satisfactory coverage (>90%) when tested against Klebsiella spp. and P. aeruginosa isolates in EU.
- Published
- 2014
- Full Text
- View/download PDF