Search

Autosomal dominant polycystic kidney disease (ADPKD) constitutes the fourth cause of end-stage renal disease in Europe. The course of the disease varies widely among patients with ADPKD. Due to the emergence of new possibilities of pharmacotherapy, it has become crucial to identify the group of patients with the fastest rate and risk of disease progression. This particular group of patients will benefit most from the therapy and they are the best candidates for clinical trials. At the early stages of ADPKD typical markers of severity and progression of the disease remain unchanged in contrast to the kidney volume, which increases continuously in an exponential way. Therefore, the use of height-adjusted total kidney volume as a biomarker should become a mandatory diagnostic option. Also, quantitative MRI techniques are promising biomarkers for the evaluation of disease severity and could provide additional insights into its course. [ABSTRACT FROM AUTHOR]

The use of pesticides is permitted in tea cultivation, but many of them are withdrawn in Europe. The aim of this study was a comprehensive assessment of pesticide occurrence in common teas (black, green, red, white, and black flavored) and herbal teas (lemon balm and mint) and their transfer to the infusion. Among 603 pesticides, 24 were detected, of which 9 were withdrawn in Europe. Of the 64 tea samples, 47% had pesticide residues and 2% exceeded the European Maximum Residue Level (EU MRL; 572% for linuron/mint). The highest mean concentrations of the most common pesticides were 336 ng g -1 (quizalofop-P-ethyl/mint), 108.4 ng g -1 (MCPA/lemon balm), and 92.4 ng g -1 (glyphosate/red tea). A short time of brewing (5 min) had a higher transfer factor (TF) of most pesticides to the infusion (TF = 0.85/thiacloprid), compared to 30 min brewing (TF = 0.75/thiacloprid). Moreover, the physicochemical properties of detected pesticides, mainly density and melting temperature had a crucial impact on their transfer to the infusion. Acute risk was the highest for linuron/mint/children (17% of Acute Reference Dose; ARfD). Despite the withdrawal of some pesticides in the EU, they are still detected in tea samples. The results are pivotal for human health and highlight the need for further legislative action for tea., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)